I Want to Stop Methotrexate

[Forest Walker]

Hi Forest..

I am not surprised. I only was able to use it for about two months and then decided that it was not for me.
I don’t know how it differs if you have an injectable. I considered the stuff as so bad for my body that I did not want it at all anymore.

MTX is an overall strong immune suppressor. The whole of the immune system is pushed downward.

TNF-alpha inhibitors block a part of the pathways in the immune system that causes the inflammation to occur. (Never used them) So it also is kind of an overall suppressor.

Interleukine or Cytokine blockers work mostly on IL-23 or IL-17 or IL-17a, and perhaps some others, but these three are the most significant for Psoriasis and Psoriatic Arthritis.
Overall it seems that IL-23 is most effective for psoriasis and IL-17 is mostly effective for Psoriatic Arthritis. Though it appears that both work more or less for both.

The interleukines often work much better than the TNF-alpha or MTX.
Indeed the work for both Psoriasis and Crohns.

Which may be logical if you consider the human body as kind of a pipe, with the skin on the outside and the stomach and intestines on the inside, so basically also the intestines are built of the same material as the skin. Ergo… the effect of the medication is on both.

Thank you, Caroline.  Your information above is an example of the knowledge in this forum.  Collectively, the experience, research, and willingness to share in this forum aid in creating a meaningful, helpful place.