I think Skilarence has stopped working

[Caroline]

I have been taking Skilarence for well over a year and with some success. It has never fully disappeared but has certainly helped. Recently my skin has had a bad flare up and I’m wondering if Skilarence has stopped working? Is this a thing? Can it stop working after a time? If yes then what might be my new options?

I am from the DMF gang.
It is unlikely that Skilarence has stopped working. It is more logical that you are experiencing a serious flare up that instabilizes the treatment.
DMF is not like biologicals, where you can build up antibodies, indeed it can be that it stops working, but as I said, it is unlikely. It may be that for a short period you may need some more, Jims also knows about that.

What is your current dose?
How is the state of your lymphocites and eosinofilen? Those two are very important in measuring how the treatment works.
Do you still get the flushes some times?

Like to hear from you

Cheers,
Caroline.

im on the full dose of 6 tablets per day and yes get the occasional hot flush. My white cells were very low at my last blood test and I have come down with this bad cold that I just can’t shift. Gutted. 

What do you mean by very low ?  If you are below 0.5 , then you certainly are too low, and then you should reduce the dose.

What do you mean by saying: “ I have come down with this bad cold that I just can’t shift. Gutted. “, in my idea that may be common English, but it probably is a way of expressing oneself and I, as a foreigner, cannot understand the real meaning, only can guess.. but still don’t know what to guess.


The full dose does not exist with DMF in the form of Skilarence, there is no problem going higher. The 6 tablets are a historical flaw derived from Fumaderm, which indeed had an upper level of six because it was mixed with mono ethyl Fumarate, which gave this limitation.
Skilarence is only DMF, so there is no problem in raising, but…. If your lymphocytes are really too low, you must not increase. The makers of Skilarence did no research on the maximum dose, they just lazily choose 6 tablets.
From Psorinovo, which is alike Skilarence and already exists for 35 years, but has a slow release , we know that we even could go to 12 tablets or higher.