Health Boards
Mon-12-10-2020, 08:44 AM
Okay..
Well there are still a lot more Biologicals, so still a number of them to try.
A pity that DMF is unavailable. I’ll tell you why.
We then need a bit of a different view of what psoriasis is. What I will tell you here is coming from my doctor. He is an internist (internal diseases) not a rheumy or a derm.
If you have swollen joints, then it would be possible to puncture them in order to research the fluids in them. And if you would look into that fluid you would find crystals of pyrodrustic acid. Those crystals cause the joint pain and inflammation.
Now where do these crystals come from?
Well they are the residue of a flawed energy cycle in the mitochondria. This cycle, the citric acid cycle, does not work correctly with people with Psoriasis and as the chemical reactions in there do not work completely the pyrodrustic acid is created as a residue.
This would lead to the conclusion that psoriasis is not a skin disease, not an auto immune disease (which is an acceptable theory because anti-bodies that belong to auto immune diseases cannot be found), but... it is a mitochondrial disease (!), who had thought of that? Well I can assure you...none of the derms or rheums, but for an internist this really makes sense.
This has never really been scientifically researched by derms or rheums, but this theory already exists for at least 35 years, and seems in fact a very logical en easy explanation and maybe (I am not completely sure) is lies on the basis of the use of DMF, invented by Schweckendiek.
What now is the role of DMF.
If you look at Wikipedia to this citric acid cycle than you will see that in one of the steps of this cycle it says: “fumarase or Fumarate”, so fumarate is an essential part of the working of this cycle.
The theory is that by increasing the amount of fumarate, the reactions in the cycle will be enhanced and the amount of residue produced will reduce or even stop, leading to the gradual slow down of both psoriasis and Psoriatic Arthritis.
The cycle will work also a little faster and generate more energy, so if you do this, body temperature rises slightly.
Now it is not possible to put fumarates in the mitochondria and also not possible to put it in a pill to swallow it. But.... it is possible to make an ester of the fumarate (DMF), that will be transformed in the body and transported to the mitochondria.
That is the reason that I use DMF. And the reason why DMF works for 50-70% of the sufferers including me. It is pointing at the origin of the disease.
Well there are still a lot more Biologicals, so still a number of them to try.
A pity that DMF is unavailable. I’ll tell you why.
We then need a bit of a different view of what psoriasis is. What I will tell you here is coming from my doctor. He is an internist (internal diseases) not a rheumy or a derm.
If you have swollen joints, then it would be possible to puncture them in order to research the fluids in them. And if you would look into that fluid you would find crystals of pyrodrustic acid. Those crystals cause the joint pain and inflammation.
Now where do these crystals come from?
Well they are the residue of a flawed energy cycle in the mitochondria. This cycle, the citric acid cycle, does not work correctly with people with Psoriasis and as the chemical reactions in there do not work completely the pyrodrustic acid is created as a residue.
This would lead to the conclusion that psoriasis is not a skin disease, not an auto immune disease (which is an acceptable theory because anti-bodies that belong to auto immune diseases cannot be found), but... it is a mitochondrial disease (!), who had thought of that? Well I can assure you...none of the derms or rheums, but for an internist this really makes sense.
This has never really been scientifically researched by derms or rheums, but this theory already exists for at least 35 years, and seems in fact a very logical en easy explanation and maybe (I am not completely sure) is lies on the basis of the use of DMF, invented by Schweckendiek.
What now is the role of DMF.
If you look at Wikipedia to this citric acid cycle than you will see that in one of the steps of this cycle it says: “fumarase or Fumarate”, so fumarate is an essential part of the working of this cycle.
The theory is that by increasing the amount of fumarate, the reactions in the cycle will be enhanced and the amount of residue produced will reduce or even stop, leading to the gradual slow down of both psoriasis and Psoriatic Arthritis.
The cycle will work also a little faster and generate more energy, so if you do this, body temperature rises slightly.
Now it is not possible to put fumarates in the mitochondria and also not possible to put it in a pill to swallow it. But.... it is possible to make an ester of the fumarate (DMF), that will be transformed in the body and transported to the mitochondria.
That is the reason that I use DMF. And the reason why DMF works for 50-70% of the sufferers including me. It is pointing at the origin of the disease.