Methotrexate - Side Effects?

[SnarkyTexan]

Howdy y'all,

A real quick rundown of my dose of Methotrexate. Also, note that my dermatologist is a man. But I interact more with the resident under him, who is a woman. So if I get gender-confused, that's why haha

My dermatologist had me start a daily regimen of folic acid 2 days before she had me start the MTX (that I skip on the days I take MTX). I was taking the MTX on Tuesday's. But because of the required labs and the clashing with my job, I had to move the dose to Wednesday. 


1. I started a 2-pill dose on April 23. 

• The first labs came back normal. I discovered I am anemic based on my lab results. I didn't know but had an idea that I am. 
  
• I also had serious heartburn. There was also occasional pressure under my sternum like gallstones. I had experienced gallstones 15 years ago after having my son. Never had that issue resolved but the pain stopped after a couple of years. I emailed my dermatologist about this symptom and she says it is not related to the MTX and to contact my primary. 
  
• No change in psoriasis
  

2. Took the 4-pill dose on May 1. 

• Labs again were normal. But I've started having issues with my job. I couldn't concentrate. Distractibility was high. 
  
• 2 days after this dose, I had a full-blown gallstone attack that had me down and out for a couple of hours. Then again another attack the next day. No clue what triggered the attack
  
• A small change in psoriasis.
  

3. Took the 6-pill dose on May 8.

• Labs were normal so dr upped the dosage. 
  
• Emailed my dr about the fatigue, distractibility and how it affects my very unique job. 
  
• Inverse psoriasis has begun to clear up.
  

4. Took the 2nd 6-pill dose on 14. (current dose)

• Fatigue has been kicking my butt. My boss has given me permission to take off early if I can't work with a clear head, providing I have the vacation/sick hours to cover.
  
• Distractability wasn't an issue until today (5 days post-dose). 
  
• I feel like my mind goes blank sometimes. I'll be doing something and stop and just think "what was I doing?" That actually happened while I was creating this thread.
  
• The inverse psoriasis was almost cleared up but seems to be making a come-back.
  
• Plaques/guttate has started clearing up on the larger areas but itches like hell. Anytime I scratch, I bleed all over the place.
  
• Psoriasis had started moving down my legs more but seems to have stopped progressing.
  

Since starting MTX, I have had a very hard time getting up for work in the morning. I find myself hitting snooze 4 or 5 times before I will draaaaag myself out of bed. My sleep patterns are all jacked. 

Today, I'm seriously freaking tired. I went to bed last night an hour earlier than I normally do. I am considering ducking out early so I can sleep some more. 

I can't figure out if it's the MTX or what going on with me. It is affecting my job. I am paid by the speed I work. My pace has slowed considerably. 

Are my symptoms normal or am I experiencing something else?

Thanks for any feedback.