Sun-26-03-2017, 23:28 PM
(Sun-26-03-2017, 11:10 AM)Bill Wrote: DMF is very active biochemically, and the reactivity with cysteine residues seems to be important. Because of this activity it is hard to see how it could work as a systemic anti-fungal i.e. Where is all the free DMF to do the job? The significance of fumaric acid is that DMF is readily metabolised after it has had its pharmacological effect. Dr Schweckendiek's ideas of how fumaric esters worked against psoriasis were wrong. What matters is that he tested his ideas and demonstrated a therapeutic effect.
Cheers,
Bill
Akoa & Kuroda demonstrated the efficacy of fumaric acid as an anti-fungal in mice infected with candida albicans. As sunlight increases fumaric acid production in the skin and we know sunlight is helpful for psoriasis I don't think it's unreasonable to suppose it is the anti-fungal action which is helpful i.e. psoriasis is some sort of fungal problem. I've certainly had success coming at it from this angle - eating a variety of natural anti-fungals. But without self biopsing and getting my childhood chemistry kit out there's no way I can easily prove this . I have demonstrated a therapeutic effect is what I'm saying, albeit to myself only.