Patients with periodontitis have a significantly elevated risk of psoriasis

[Fred]

We have a few of these studies on Psoriasis Club and this one concludes that patients with periodontitis have a significantly elevated risk of psoriasis.

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Background:
The association between periodontitis and systemic diseases has been increasingly recognized. However, the data on the association between periodontitis and psoriasis are still limited.

Objectives:
To summarize all available data on the association between periodontitis and the risk of psoriasis.

Methods:
Two investigators independently searched published studies indexed in MEDLINE and EMBASE databases from inception to July 2016 using a search strategy that included terms for psoriasis and periodontitis. Studies were included if the following criteria were met: (i) case–control or cohort study comparing the risk of psoriasis in subjects with and without periodontitis; (ii) subjects without periodontitis were used as comparators in cohort studies while participants without psoriasis were used as controls in case–control studies; and (iii) effect estimates and 95% confidence intervals (CI) were provided. Point estimates and standard errors from each study were extracted and combined together using the generic inverse variance technique described by DerSimonian and Laird.

Results:
Two cohort studies and three case–control studies met the inclusion criteria and were included in the meta-analysis. The pooled risk ratio of psoriasis in patients with periodontitis versus comparators was 1.55 (95% CI, 1.35–1.77). The statistical heterogeneity was insignificant with an I2 of 18%. Subgroup analysis according to study design revealed a significantly higher risk among patients with periodontitis with a pooled RR of 1.50 (95% CI, 1.37–1.64) for cohort studies and a pooled RR of 2.33 (95% CI, 1.51–3.60) for case–control studies.

Conclusions:
Patients with periodontitis have a significantly elevated risk of psoriasis.

Source: onlinelibrary.wiley.com

*Funding: National Center for Advancing Translational Sciences (NCATS). National Institutes of Health (NIH)