Elevated neural innervation in psoriatic lesions

[Fred]

This review aims to examine the alterations in neural innervation within psoriatic skin and delineate the functional contributions of sensory neuron-derived mediators—including ion channels, receptors, and neuropeptides—in modulating psoriasis-associated immune dysregulation.

Quote:

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Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic inflammation.

Sensory neurons not only perceive various external stimuli but also participate in skin immune regulation and barrier repair through the release of neuropeptides and neurotransmitters.

This review systematically compiles current research advancements concerning the altered neural innervation patterns in psoriatic lesions, the pathophysiological functions of sensory neuron-specific receptors and ion channels, and the regulatory mechanisms of neuropeptides in disease pathogenesis.

By elucidating the precise contributions of sensory neurons to the development of psoriasis, this work seeks to further clarify their specific role in the disease and provide new insights for enhancing the understanding of its pathogenesis, thereby informing the development of more targeted therapeutic strategies.

Source: onlinelibrary.wiley.com

*Funding: National Natural Science Foundation of China

[Caroline]

This seems the other way around.

As the skin is psoriatic, you check out what this does with the immune system.

While we know that it’s the immune system that creates the psoriasis.

But… there could be kind of a feedback mechanism in the skin that could make the effects worse.