Gluten free diet could help psoriasis

[Fred]

Background: 
Patients with psoriasis who had raised IgG and/or IgA antigliadin antibodies showed clinical improvement in a trial with a gluten-free diet. The selection of patients for the diet treatment was based on the presence of specific antibodies, i.e. the result of humoral immunity.

Objectives: 
As psoriasis is now considered to be a T cell-mediated disease we decided to challenge peripheral blood mononuclear cells (PBMCs) in vitro from randomly selected patients with well-defined wheat proteins/peptides to explore the possibility of identifying a specific antigen with T cell activating properties in a subgroup of patients.

Methods: 
PBMCs from 37 patients (20 female and 17 male; mean age 49 years) and 37 healthy controls (12 female and 25 male; mean age 57 years) were included. Not all patients participated in all experiments. The PBMCs were exposed in vitro with the following wheat proteins/peptides in various concentrations: total albumins, 0·28 α-amylase inhibitor and the synthetic peptides, p31–43, p57–68 and p62–75, based on coeliac-active sequences of α-gliadin. The proliferative response was measured as counts per minute after the cells had been pulsed with methyl-3H-thymidine.

Result:  Albumin, α-amylase inhibitor, p31–43 and p57–68 elicited a significant response in both patients and controls but showed no differences between the groups. The response induced by the α-amylase inhibitor was higher than that induced by the albumin fraction and the p31–43 and p57–68 peptides. At a concentration of 25 μg mL−1, five of 36 patients with psoriasis responded positively to the p62–75 peptide and none of the 33 controls, using a stimulation index of 2·4 as the cut-off level (P < 0·05). These five patients did not show clinical features that differed from the remaining patients. Among the responding patients the relative number of CD4+ cells increased in some but not all after in vitro challenge with the albumins, 0·28 α-amylase inhibitor, and p62–75. These antigens could also induce in vitro the expression of the homing antigen cutaneous lymphocyte antigen (CLA) in a few patients and controls.

Conclusions:  The wheat protein antigens, especially the p62–75 peptide, might be of interest in a subgroup of patients with psoriasis.

Source: British Journal of Dermatology onlinelibrary.wiley.com

[Caroline]

Oh, over here psoriasis is considered a T-cell mediated disease.
Puff, you must have guts to think of all this. It might be true of course, it's not me who will decide about that, just being a bit critical.

And what if it is a disturbance in the citric acid cycle of the cell? What they already found out more than ten years ago?
The citric acid cycle is essential in the delivery of energy towards your cells. If it hampers in a certain way, they you will get the appearance on your skin that they call psoriasis.

[Fred]

Oh, over here psoriasis is considered a T-cell mediated disease.
Puff, you must have guts to think of all this. It might be true of course, it's not me who will decide about that, just being a bit critical.

And what if it is a disturbance in the citric acid cycle of the cell? What they already found out more than ten years ago?
The citric acid cycle is essential in the delivery of energy towards your cells. If it hampers in a certain way, they you will get the appearance on your skin that they call psoriasis.

Puff indeed my dear.

[JustSuzy]

I went gluten and sugar free for a few months and it made no difference in my case.

Suzy

[Caroline]

More fun from the National Psoriasis Foundation.
They state:"If a gluten-free diet may help reduce psoriasis for some people,
could it help psoriatic arthritis, too?

Like with psoriasis, the answer is: It might, if gluten is part of the problem. "

Well I guess they are serious but a bit clumsy.
Let's extrapolate:
If a wine-free diet may help reduce psoriasis for some people,
could it help psoriatic arthritis, too?
Like with psoriasis, the answer is: It might, if wine is part of the problem.
And:
If a porc-free diet may help reduce psoriasis for some people,
could it help psoriatic arthritis, too?
Like with psoriasis, the answer is: It might, if porc is part of the problem.

You can imagine, I can continue for a while like this. It is quite something like an open door.
Still of course, as psoriasis has something to do with the immune system and the energy cycle of the cells, then food, in one way or another can very well have an effect on psoriasis.

An example. A few years ago, I followed the Aquatilis Therapy of dr. Essaïdi. It is a therapy with all kinds of electromagnetic radiation. 6 treatments.
At the fifth treatment I got in addition a little drink made out of 35 different herbs and camel milk, a family recipe.
I went home.
In the middle of the night I woke up. Not just a wake up, no I WOKE UP !! The energy in my body really washed over the edge, I had to get up and do something otherwise I would explode! So I got up, jumped on my bike and biked very speedy to the sea. Over there I parked my bike and went for a walk in the dunes. It was still dark but slowly getting lighter, dawn they call it i guess.
Fast shadows of deer moved around me, and gradually I came back to my senses. After a good walk I biked back home again.
That next week all symptoms of my arthritic psoriasis disappeared. No more painful fingers and feet, all gone.
So that was it! The potion, the little drink, made the difference. So I kept on drinking it, btw it had an awful taste.
But after a while the symptoms came back, the drink seemed also to change of ingredients. Also asking about the ingredients did not help, it appeared that this dr. Essaïdi had the drink made by his mother and that he had no idea of what was in it. So much for "a therapy" haha, my belief in it stopped immediately.
Finally this also appeared to be a dead end, or it should be that the radiation caused the change, but intuitively I doubt that.
Anyway, for me it proved, that there is a substance that has an effect on the immune system, or on the energy cycle, and that has a significant effect on psoriasis.

[leopardless]

I agree with you.

More fun from the National Psoriasis Foundation.
They state:"If a gluten-free diet may help reduce psoriasis for some people,
could it help psoriatic arthritis, too?

Like with psoriasis, the answer is: It might, if gluten is part of the problem. "

Well I guess they are serious but a bit clumsy.
Let's extrapolate:
If a wine-free diet may help reduce psoriasis for some people,
could it help psoriatic arthritis, too?
Like with psoriasis, the answer is: It might, if wine is part of the problem.
And:
If a porc-free diet may help reduce psoriasis for some people,
could it help psoriatic arthritis, too?
Like with psoriasis, the answer is: It might, if porc is part of the problem.

[SoupHero]

I went gluten free to get rid of a face eczema and cleared my mild scalp and nail psoriasis I had for 30 years as a side effect. I understand that that may not be the the cure for everyone but it is worth the try. Later I have realised that I probably had leaky gut since early childhood (lots of antibiotics, damaged gut flora).

Doctors prepared me for the fact that psoriasis will be my companion for the rest of my life and when I told my dermatologist he did not believe. The medical science does not have all answers and even those that exist are ignored by medical practice. Self experimentation is key.

[Brighteyes]

I've cut back heavily on the gluten ( OK I do have the occasional lapse but I'm not a saint).
It wasn't because of my Psoriasis though, it was because of painful bloating and other stuff. I do feel much better without it. Whether it helped with the Psoriasis is debatable but I feel much better in myself so that's the main thing.