This German study looked at effectiveness, safety and impact of Tremfya (guselkumab) on sexuality and perceived stigmatization in patients with psoriasis.

Quote:

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Background:
G-EPOSS is a prospective, non-interventional, German multicentre study of patients with moderate-to-severe plaque psoriasis receiving guselkumab, a therapeutic monoclonal antibody targeting interleukin-23, in a real-world setting.

Objectives:
The objective of the study was to evaluate the effectiveness and safety of guselkumab, including its impact on skin, health-related quality of life (HRQoL), sexuality, and perceived stigmatization.

Methods:
Patients (≥18 years old) received guselkumab per routine clinical practice. The primary endpoint was the proportion of patients achieving absolute Psoriasis Area and Severity Index (PASI) ≤ 3 at Week (W)28. Secondary endpoint assessments over 28 weeks included the Nail Psoriasis Severity Index (NAPSI), anogenital Physician's Global Assessment (aPGA), and Dermatology Life Quality Index (DLQI). Sexuality and perceived stigmatization were assessed by patients using the Relationship and Sexuality Scale (RSS) and Perceived Stigmatization Questionnaire (PSQ), respectively.

Results:
Overall, 293 patients were included in the evaluable set population. Mean age and disease duration were 45.6 and 17.6 years, respectively. At baseline, mean PASI, aPGA and DLQI scores were 15.3, 2.7 and 11.3, respectively. In total, 25.9% of patients had received a prior biologic. Overall, 83.0% of patients achieved PASI ≤ 3, and 56.2%/35.1% achieved PASI ≤ 1/PASI = 0, respectively, at W28. Among those with NAPSI ≥ 1 and aPGA ≥ 1 at baseline, NAPSI = 0 and aPGA = 0 were achieved by 39.2% and 61.1% of patients, respectively, and 61.4% of patients achieved DLQI 0–1 at W28. Improvements were observed over 28 weeks across individual items of the DLQI, RSS and PSQ, indicating improved HRQoL and sex life, and decreased perceived stigmatization. Based on DLQI Question (Q)9, 53.6% of patients experienced sexual difficulties at baseline, which decreased to 12.1% at W28. DLQI Q9 responses were consistent with RSS item responses, highlighting DLQI Q9 as a sentinel for sexual impairment.

Conclusions:
Guselkumab improved overall skin symptoms and HRQoL in patients with psoriasis and decreased sexual impairment and perceived stigmatization. No new safety signals were observed.

Source: onlinelibrary.wiley.com

*Funding: Projekt DEAL

Tremfya (guselkumab)

This sounds like… you have to use Tremfya to get better sex…

But to my opinion there is no primary relation between Tremfya and better sex, but there is a relation between no visible psoriasis and better sex, I can imagine that.
So the relations is at best secundary.

(Fri-12-04-2024, 17:34 PM)Caroline Wrote: This sounds like… you have to use Tremfya to get better sex…

But to my opinion there is no primary relation between Tremfya and better sex, but there is a relation between no visible psoriasis and better sex, I can imagine that.
So the relations is at best secundary.

Disclaimer: Other treatments are available to give you better sex. 

But on a serious note you are right and I would imagine for some people psoriasis and sex can be very difficult, it's all about getting your self esteem back and having a good partner.

One has to wonder who determines what to do studies on. I mean does someone say I had better sex and I take "x drug" so they do a study on it? Or maybe someone would say "Since taking "x drug" my little toe on my left foot is tingly" and they do a study on that? And how many people are commenting on having better sex and doctors reporting it and wouldn't they wonder if that came from just having more confidence or do they automatically go hmm, wonder if the drug is helping?

I'm beginning to understand why I don't have a scientific mind.

I do understand the why on some studies, but sometimes I wonder why they study certain things.

Anyway................

(Tue-30-04-2024, 13:17 PM)Kat Wrote: One has to wonder who determines what to do studies on.  I mean does someone say I had better sex and I take "x drug" so they do a study on it?  Or maybe someone would say "Since taking "x drug" my little toe on my left foot is tingly" and they do a study on that?  And how many people are commenting on having better sex and doctors reporting it and wouldn't they wonder if that came from just having more confidence or do they automatically go hmm, wonder if the drug is helping? 

I'm beginning to understand why I don't have a scientific mind. 

I do understand the why on some studies, but sometimes I wonder why they study certain things.

Anyway................

Sometimes I never understand why they do so some studies, but then again I guess any study is better than none.

(Tue-30-04-2024, 13:31 PM)Fred Wrote:

(Tue-30-04-2024, 13:17 PM)Kat Wrote: One has to wonder who determines what to do studies on.  I mean does someone say I had better sex and I take "x drug" so they do a study on it?  Or maybe someone would say "Since taking "x drug" my little toe on my left foot is tingly" and they do a study on that?  And how many people are commenting on having better sex and doctors reporting it and wouldn't they wonder if that came from just having more confidence or do they automatically go hmm, wonder if the drug is helping? 

I'm beginning to understand why I don't have a scientific mind. 

I do understand the why on some studies, but sometimes I wonder why they study certain things.

Anyway................

Sometimes I never understand why they do so some studies, but then again I guess any study is better than none.

True. And I'm sure most pharms would love to find multi-use benefits (Ozempic comes to mind) so they can make more $$. But if a drug has muti benefits than that's a good thing.

And since studies are (mostly) from parties that don't profit, it's good to find out when a drug has some "bad" things associated it with as well.

So studies are important.

(Thu-02-05-2024, 00:39 AM)Kat Wrote:

(Tue-30-04-2024, 13:31 PM)Fred Wrote:

(Tue-30-04-2024, 13:17 PM)Kat Wrote: One has to wonder who determines what to do studies on.  I mean does someone say I had better sex and I take "x drug" so they do a study on it?  Or maybe someone would say "Since taking "x drug" my little toe on my left foot is tingly" and they do a study on that?  And how many people are commenting on having better sex and doctors reporting it and wouldn't they wonder if that came from just having more confidence or do they automatically go hmm, wonder if the drug is helping? 

I'm beginning to understand why I don't have a scientific mind. 

I do understand the why on some studies, but sometimes I wonder why they study certain things.

Anyway................

Sometimes I never understand why they do so some studies, but then again I guess any study is better than none.

True.  And I'm sure most pharms would love to find multi-use benefits (Ozempic comes to mind) so they can make more $$.  But if a drug has muti benefits than that's a good thing.

And since studies are (mostly) from parties that don't profit, it's good to find out when a drug has some "bad" things associated it with as well.

So studies are important.

But….. they will only do that if they have a clear vision that they can earn something with it..

If it seems that no profit can be made, and that it even can become cheaper for patients, then I doubt that a study will be performed.

JJ has killed their own research when things weren’t looking good. It completely sucks from a consumer standpoint - especially at the price point we or governments pay.