(Wed-29-06-2022, 16:29 PM)Forest Walker Wrote: This IS a very wonderful site.  I agree with you, Bill.     Thank you, again, Fred.

(Wed-29-06-2022, 19:31 PM)Fred Wrote:

(Wed-29-06-2022, 16:29 PM)Forest Walker Wrote: This IS a very wonderful site.  I agree with you, Bill.     Thank you, again, Fred.

(Wed-29-06-2022, 20:47 PM)Caroline Wrote:

(Wed-29-06-2022, 19:31 PM)Fred Wrote:

(Wed-29-06-2022, 16:29 PM)Forest Walker Wrote: This IS a very wonderful site.  I agree with you, Bill.     Thank you, again, Fred.

Oops sorry Bill I'm going off topic.

Go for it Fred. My treatment is going well, so hopefully I can roll on without the need to experiment to solve problems for a good while.

Cheers

Great to see your results Bill looks like all your numbers are staying good the lymphocytes are looking great at 1.5.  And they have been around the same for over a year now, so you must be doing something right . My lymphocytes are at 1.2 at the moment so I'm very happy with that although psoriasis is creeping back into my scalp, but I hope that's just a stress thing and will calm down soon

Keep up the good work with your dmf  it's always good to see an update from you

Thank you Jim. 1.2 is a good count, but anything 0.9 or higher is good as long as the value is stable. I think we have been having tests for long enough to know that the count is pretty stable, but having had sudden drops in the lymphocyte count, with and without symptoms, I well understand why you have them often.

Cheers

Time for an update:



I have been dosing around five times a week with supplements and note a drop in lymphocytes. The psoriasis remains well controlled but I have developed a few fingerprint sized patches. Since the test I have decided to try another dosing strategy. NAC inhibits the anti-oxidant/anti-inflammatory NRF2 activation of dmf, so while it helps the lymphocyte count, it reduces the efficacy of dmf. By not taking supplements with dmf and dosing about three times weekly I may get equal or better efficacy from the drug. In line with this the new patches have been resolving. I expect to have a drop in lymphocytes with my next blood test, but I think that it will be a better approach to take a break from dmf and take supplements if the lymphocyte count drops too low. I hope that this approach will make treatment simpler and more effective. On a lighter note I have been taking advantage of the cheap strawberries on offer by making lots of jam. I make mine with a whack of lemon so it isn't too sweet. Very yummy.

Cheers

(Fri-21-10-2022, 05:07 AM)Bill Wrote: Time for an update:



I have been dosing around five times a week with supplements and note a drop in lymphocytes. The psoriasis remains well controlled but I have developed a few fingerprint sized patches. Since the test I have decided to try another dosing strategy. NAC inhibits the anti-oxidant/anti-inflammatory NRF2 activation of dmf, so while it helps the lymphocyte count, it reduces the efficacy of dmf. By not taking supplements with dmf and dosing about three times weekly I may get equal or better efficacy from the drug. In line with this the new patches have been resolving. I expect to have a drop in lymphocytes with my next blood test, but I think that it will be a better approach to take a break from dmf and take supplements if the lymphocyte count drops too low. I hope that this approach will make treatment simpler and more effective. On a lighter note I have been taking advantage of the cheap strawberries on offer by making lots of jam. I make mine with a whack of lemon so it isn't too sweet. Very yummy.

Cheers

You are still doing very well with this count of the lymphocytes, Bill.

Do I understand it well that you are for now have completely stopped the supplements?
And If the lympho’s go down, that you will completely stop the DMF, and then will only take the supplements for a while?

Do you have an idea of how long you will stop the DMF then? Days - weeks?
Arent you worried that the Psoriasis will come back then?
How would you restart after the break, as often with the start the lympho’s plunge (as far as I know)

Couldn’t it be an approach to, for now stop the supplements for not too long, wait for the patches to go away, and then after some time, restart the supplements again? So without stopping the DMF.

Which range of supplements have you been taken the recent time?

Oops…. Questions, questions, I realise, so early in the morning. Oh. for you it is not early in the morning.

Cheers,
Caroline

Hi Caroline,

I suspect that dmf works better without supplements, or at least without NAC. I will take it less frequently (three doses of about 530mg a week). If I get a blood test with a lymphocyte count of less than 1 I will cease taking dmf and instead take a daily supplement of nac, glutamine and creatine until I have another blood test about a month later. That is my plan, so hopefully it will work.

Cheers

(Fri-21-10-2022, 07:01 AM)Bill Wrote: Hi Caroline,

I suspect that dmf works better without supplements, or at least without NAC. I will take it less frequently (three doses of about 530mg a week). If I get a blood test with a lymphocyte count of less than 1 I will cease taking dmf and instead take a daily supplement of nac, glutamine and creatine until I have another blood test about a month later. That is my plan, so hopefully it will work.

Cheers

Good luck with your approach Bill
It feels as a very controlled and solid approach.