This study looked at psoriasis and the progression of parkinson’s disease.

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Background:
Epidemiological studies have suggested psoriasis was associated with an increased risk of Parkinson’s disease (PD). However, whether psoriasis has an effect on PD progression is not explored yet.

Objectives:
To evaluate the causal role of psoriasis in PD progression.

Methods:
We conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association study of psoriasis (N=33,394), age at onset (N=28,568) and progression (N=4,093) of PD.

Results:
One standard deviation increase in genetically determined psoriasis risk was significantly associated with faster progression to dementia (OR=1.07, 95 % CI: 0.1.03~1.1, P=4.71E-04). Meanwhile, higher psoriasis risk was nominally associated with faster progression of PD measured by time to Hoehn and Yahr stage 3 (OR=1.05, 95 % CI: 1.02~1.08, P=1.53E-03) and depression (OR=1.06, 95 % CI: 1.02~1.11, P=1.77E-03) of PD. The results were robust under all sensitivity analyses.

Conclusions:
These results suggested psoriasis accelerated overall progression of PD, and increased risk of dementia and depression of PD. A deeper understanding of neuroinflammation and immune response is likely to elucidate the potential pathogenesis of PD progression and identify novel therapeutic targets.

Source: onlinelibrary.wiley.com

*Early view funding unknown. 

Do we have anyone with Parkingson in Psoriasisclub ?

(Sun-31-07-2022, 07:15 AM)Caroline Wrote: Do we have anyone with Parkingson in Psoriasisclub ?

Not that I recall.

A bit frightening in some respects, just lost a friend to PD and it was not a good experience.

Terrible disease, lost an "aunt" last year.  Don't want that one on my list of ailments!!!!

Yes we witnessed a neighbour go that way, it's horrible.

(Sun-31-07-2022, 07:15 AM)Caroline Wrote: Do we have anyone with Parkingson in Psoriasisclub ?

I have a worry about that. My Gran had it and as it skips a generation, I worry about that. Didn't become apparent in Gran until her mid 60's. At least that is when she was diagnosed. That was in the early 80's though so diagnoses were not accurate as they are today, nor as prevalent.