Treating stubborn psoriasis patches with biologics

[Fred]

This Japanese study evaluated the treatment outcomes of stubborn (refractory) regions of psoriasis and psoriatic arthritis treated with biologics.

Quote:

---

Systemic therapies are required to control disease severity of patients with psoriasis vulgaris (PsO) and psoriatic arthritis (PsA) experiencing refractory skin lesions that persisted despite systemic therapies.

Various oral medications and biologics are currently available in Japan. The aim of this study was to evaluate the treatment outcomes of refractory regions of PsO and PsA treated with systemic therapy. A total of 77 patients who received oral medications and biologics between 1 January 2010 and 31 March 2019 at the Jichi Medical University Hospital were enrolled.

The PsO group included 39 men and 11 women, whereas the PsA group included 20 men and 7 women. Oral medications included etretinate (7 PsO patients and 3 PsA patients), cyclosporine (39 PsO patients and 20 PsA patients), apremilast (7 PsO patients), and methotrexate (5 PsA patients), including 4 patients treated with etretinate and cyclosporine combination (3 PsO patients and 1 PsA patient). The biologics included infliximab (5 PsO patients and 8 PsA patients), adalimumab (11 PsO patients and 11 PsA patients), ustekinumab (21 PsO patients and 6 PsA patients), guselkumab (5 PsO patients), secukinumab (2 PsO patients and 1 PsA patient), ixekizumab (5 PsO patients and 1 PsA patient), and brodalumab (1 PsO patient).

The most common biologic-resistant regions were the lower extremities, followed by the upper extremities and back in patients with PsO, and the scalp, followed by the lower extremities and abdomen in patients with PsA. Despite the introduction of biologics, no significant differences were observed in the efficacy on the face, neck, palm, and buttocks in patients with PsO and the face, sole, and buttocks in patients with PsA compared to oral medications.

These findings will provide useful information regarding biologic-resistant psoriatic regions in the Japanese patients.

Source: onlinelibrary.wiley.com

*Funding: Early view funding unknown

[mataribot]

lol, sounds like they don’t want pay for better medicine. Most of the oral medicine on that list doesnt work at all for PsA and the one that has an approval went through three phase 3 trials and blamed it on back arthritis.

[Fred]

lol, sounds like they don’t want pay for better medicine. Most of the oral medicine on that list doesnt work at all for PsA and the one that has an approval went through three phase 3 trials and blamed it on back arthritis.

[glenda grant]

I am on Skyrizi injection every 90 days it has really worked well on me. I had psoriasis 60% of my body and now i am clear the cost of the shot is $20,000 thank goodness my husband was a Veteran and i am covered under widows benefits here in USA. That price is ridiculous who could afford that,I am fortunate for sure.
I had to get a new Rheumatologist she is a young Dr she put me on a pill LEFLUNOMIDE 10 MG once a day she is checking my blood for my liver count it is ok the pill is part of a treatment for my psoriatic arthritis been on it for a month so hopefully it will help.my legs have been hurting me so bad especially at night they ache i have bad knees and they want to do a replacement one at a time i am holding off .I get cortisone shots every 3 months helps for a while. I need to lose some weight I had recently gained 12 lbs i am working to get it off. They say taking it off will take pressure off which is true. So i will give it my best.