Psoriasis treated with dithranol

[Fred]

The aim of this pilot study was to assess the effect of repeated dithranol applications on aspects of histopathologic features of psoriasis.

Quote:

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Background:
There are only limited histomorphological data on the response of psoriatic skin lesions to topical dithranol. In vivo reflectance confocal microscopy (RCM) in psoriatic skin is highly correlated with histopathological findings and allows non-invasive monitoring of treatment effects on a cellular level.

Patients and Methods:
Prospective, single-center pilot study at a university-based clinic of dermatology between January 1st and August 30th, 2016. Psoriatic lesions of 20 patients receiving dithranol treatment were assessed by RCM at baseline, day 4 and 8 of treatment.

Results:
RCM measurements of psoriatic lesions receiving dithranol treatment revealed epidermal histomorphological changes with a strong median reduction of baseline hyperkeratosis by 45.0% (p < 0.001), acanthosis by 38.2% (p < 0.001), and epidermal thickness by 66.5% (p < 0.001) from baseline until day 8. Moreover, semiquantitative measurements of parakeratosis also showed a significant reduction until day 8 (p < 0.001). Correspondingly, RCM revealed dermal histomorphological changes with a decrease in diameter of dermal papillae by 32.1% (p < 0.001), decrease in diameter of papillary vessels by 16.9% (p = 0.002) and a strong semiquantitative reduction of the inflammatory infiltrate (p < 0.001).

Conclusions:
Results from our pilot study indicate that topical dithranol treatment of psoriatic lesions may induce a rapid and marked reduction of pathologic epidermal and dermal RCM features.

Source: onlinelibrary.wiley.com

*Funding: Projekt DEAL

[Caroline]

Isn’t this a very old treatment ?
Is it still being used?
And is the number of 20 patients not very very low?

It basically says:
“Within just a week, dithranol treatment can markedly improve both the outer and deeper skin structure in psoriasis, reducing thickened skin layers, abnormal cells, enlarged blood vessels, and inflammation.”

But they took the long way of stating that.

[Fred]

Isn’t this a very old treatment ?
Is it still being used?
And is the number of 20 patients not very very low?

It basically says:
“Within just a week, dithranol treatment can markedly improve both the outer and deeper skin structure in psoriasis, reducing thickened skin layers, abnormal cells, enlarged blood vessels, and inflammation.”

But they took the long way of stating that.

Yes

Yes

Agree

But it gave us a thread.

[Caroline]

Isn’t this a very old treatment ?
Is it still being used?
And is the number of 20 patients not very very low?

It basically says:
“Within just a week, dithranol treatment can markedly improve both the outer and deeper skin structure in psoriasis, reducing thickened skin layers, abnormal cells, enlarged blood vessels, and inflammation.”

But they took the long way of stating that.

Yes

Yes

Agree

But it gave us a thread. 

You mean this whole research has completely been done for us?

[mataribot]

Sounds like someone is trying to be a tightwad.