Metabolic syndrome and psoriatic arthritis

[Fred]

This cohort aimed to explore the association between metabolic syndrome (MetS) and radiographic features (peripheral and axial) in psoriatic arthritis (PsA).

Quote:

---

Objectives:
Metabolic syndrome (MetS) is a known comorbidity of psoriatic arthritis (PsA) and is associated with PsA disease activity. We aimed to explore the association between MetS and radiographic features (peripheral and axial) in PsA.

Methods:
We included patients with PsA followed at our prospective observational cohort for the period between 1978 and 2024. We identified patients with MetS on longitudinal follow-up and used generalized estimating equations (GEE) analysis to define the radiographic features independently associated with MetS, adjusting for age, sex, PsA disease duration, calendar decade, and use of targeted disease modifying anti-rheumatic drugs.

Results:
The study population consisted of 1422 patients, out of which 400 (28.1%) had MetS at baseline (clinic entry) and 836 (58.79%) ever had a record of MetS (per the harmonized definition by Alberti et al.) over a median [interquartile range] follow-up duration of 10.59 [4.52, 18.28] years. The mean (standard deviation [SD]) age of our cohort at baseline was 44.43 (12.98) years, with 789 (55.5%) patients identifying as male. Mean (SD) body mass index was 28.79 (6.36) kg/m2. In the GEE analysis, MetS was not significantly associated with axial disease or radiographic damage to peripheral joints, assessed as the presence of syndesmophytes or sacroiliitis and the radiographic damaged joint count, respectively. On the other hand, MetS was significantly associated with calcaneal spurs, diffuse idiopathic skeletal hyperostosis, and degenerative disc disease.

Conclusion:
MetS is associated with degenerative and metabolic changes in the spine and entheses, but not with radiographic damage in PsA.

Source: onlinelibrary.wiley.com

*Funding: Early view funding unknown

[Caroline]

Well at least that is one comorbidity less.