COVID-19 and mortality in psoriasis and psoriatic arthritis

[Fred]

This study looked at the mortality trends of Psoriasis (PsO) and Psoriatic arthritis (PsA) between 2010 and 2021, focusing on the effects of the COVID-19 pandemic.

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Background:
Little is known about mortality trends among patients with psoriasis (PsO) and psoriatic arthritis (PsA) in the United States.

Objectives:
To ascertain mortality trends of PsO and PsA between 2010 and 2021, focusing on the effects of the COVID-19 pandemic.

Methods:
We collected data from the National Vital Statistic System and calculated age-standardized mortality rates (ASMR) and cause-specific mortality for PsO/PsA. We evaluated observed versus predicted mortality for 2020–2021 based on trends from 2010 to 2019 with joinpoint and prediction modelling analysis.

Results:
Among 5810 and 2150 PsO- and PsA-related deaths between 2010 and 2021, ASMR for PsO dramatically increased between 2010–2019 and 2020–2021 (annual percentage change [APC] 2.07% vs. 15.26%; p < 0.01), leading to a higher observed ASMR (per 100,000 persons) than predicted for 2020 (0.27 vs. 0.22) and 2021 (0.31 vs. 0.23). The excess mortality of PsO was 22.7% and 34.8% higher than that in the general population in 2020 (16.4%, 95% CI: 14.9%–17.9%) and 2021 (19.8%, 95% CI: 18.0%–21.6%) respectively. Notably, the ASMR rise for PsO was most pronounced in the female (APC: 26.86% vs. 12.19% in males) and the middle-aged group (APC: 17.67% vs. 12.47% in the old-age group). ASMR, APC and excess mortality for PsA were similar to PsO. SARS-CoV-2 infection contributed to more than 60% of the excess mortality for PsO and PsA.

Conclusions:
Individuals living with PsO and PsA were disproportionately affected during the COVID-19 pandemic. Both ASMRs increased at an alarming rate, with the most pronounced disparities among the female and middle-aged groups.

Source: onlinelibrary.wiley.com

*Funding: National Natural Science Foundation of China

[Caroline]

There are several things that are totally not clear in this study, which I think is very important concerning the people who have PsO or Psoriatic Arthritis

1. What is the difference in mortality between the groups of vaccinated and non vaccinated people?
2. I would like to see a more detailed view between the various medications the deceased people were having for their treatment.

Those two are very important. Now it is just a pile of data that does say something, but as people with pso or psa are very different it does not say very much.
I will have a check over here in the database that is kept by the hospitals.

I would like to know 1 and 2, as medication can be very important, e.g. it is known that MTX is significantly lowering your immune system reaction. Which can either be good or bad with at covid infection.

From the international psoprotect database.







So very low deathrate.



High BMI !! …

[D Foster]

As far as I can see it's bordering on total rubbish. It's not taking into account so many other factors including the lack of care, the vaccine it's self which only now the true implications are starting to appear especially in females.

[jiml]

I agree with Caroline there is so much more that is needed as the figures seem to assume that the psoriasis contributed to the deaths when it would more likely be medication altering immune systems allowing COVID easy access to infect us

I'm afraid I don't understand Caroline's charts