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Psoriasis Club › HealthHealth Boards › Psoriasis And Psoriatic Arthritis Topics & News v
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Skyrizi psoriatic arthritis phase 3 results

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Skyrizi psoriatic arthritis phase 3 results
Fred Offline
I Wanted To Change the World But Got Up Far Too Late.
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#1
News  Tue-05-01-2021, 16:26 PM
Skyrizi (risankizumab) Phase 3 Results Demonstrate Improvements in Disease Activity Across Joint and Skin Symptoms Among Psoriatic Arthritis Patients.

Quote:
AbbVie today announced positive top-line results from two Phase 3 studies in adults with active psoriatic arthritis, KEEPsAKE-1 and KEEPsAKE-2, showing that significantly more patients treated with risankizumab (150 mg) achieved the primary endpoint of ACR20 response at week 24 versus placebo. In KEEPsAKE-1 and KEEPsAKE-2, 57 and 51 percent of patients receiving risankizumab achieved ACR20 response at week 24, respectively, versus 34 and 27 percent receiving placebo (p<0.001).

Results of ranked secondary endpoints showed significant improvements in skin clearance (as measured by at least a 90 percent improvement in Psoriasis Area Severity Index [PASI 90]), physical function (as measured by the Health Assessment Questionnaire Disability Index [HAQ-DI]) and minimal disease activity (MDA) at week 24. These two Phase 3 studies evaluated risankizumab in adult patients with active psoriatic arthritis, and included patients who had responded inadequately or were intolerant to biologic therapy and/or non-biologic disease-modifying anti-rheumatic drugs (DMARDs).

"We are encouraged by these positive results showing the potential of risankizumab in psoriatic arthritis," said Michael Severino, M.D., vice chairman and president, AbbVie. "These results underscore our commitment to research that can provide health care practitioners with important treatment options for patients with psoriatic disease."

Source: abbvie.com

Risankizumab - Skyrizi
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KatT Offline
100 + Member I Just Cant Stop !
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#2
Tue-05-01-2021, 23:47 PM
Clap  another one coming soon!  Last time I looked at what was available here, Skyrizi was not on the list for PSA.
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Fred Offline Author
I Wanted To Change the World But Got Up Far Too Late.
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Posts: 46,870
Threads: 3,136
Joined: Aug 2011
Sex: Male
Location: France
Psoriasis Score: 2
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Treatment: Tremfya / Coconut Oil
#3
Tue-05-01-2021, 23:53 PM
(Tue-05-01-2021, 23:47 PM)KatT Wrote: Clap  another one coming soon!  Last time I looked at what was available here, Skyrizi was not on the list for PSA.

They usually get psoriasis under their belt first then go for psoriatic arthritis, it's the easier rout.  Wink
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Caroline Offline
You must hurry if you ever want to catch a chicken...
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#4
Wed-06-01-2021, 09:24 AM
(Tue-05-01-2021, 23:53 PM)Fred Wrote:
(Tue-05-01-2021, 23:47 PM)KatT Wrote: Clap  another one coming soon!  Last time I looked at what was available here, Skyrizi was not on the list for PSA.

They usually get psoriasis under their belt first then go for psoriatic arthritis, it's the easier rout.  Wink

It also makes sense that Psoriasis bio’s are also working for Psoriatic Arthritis, as both diseases are instances of the same problem.
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