Taltz beats Tremfya in head to head

[Fred]

Eli Lilly makers of Taltz say they have beaten Tremfya in a head to head study.

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Eli Lilly today presented detailed data at the 5th Annual Maui Derm NP+PA Fall meeting from the Phase 4 IXORA-R study, the first head-to-head (H2H) study between an IL-17A inhibitor and an IL-23/p19 inhibitor using the Psoriasis Area Severity Index (PASI) 100 score as the primary endpoint. Taltz met the primary endpoint of superiority vs. TREMFYA in the proportion of patients with moderate to severe plaque psoriasis achieving complete skin clearance as measured by PASI 100 at Week 12, as well as key secondary endpoints. The study is ongoing through Week 24.

"Healthcare providers and patients value speed of response when evaluating treatment options for moderate to severe plaque psoriasis," said lead study investigator Andrew Blauvelt, M.D., M.B.A., dermatologist and president of Oregon Medical Research Center in Portland, OR. "The results from the IXORA-R study demonstrate that Taltz was effective in helping more patients achieve completely clear skin by Week 12, with a 50 percent improvement in skin plaques seen as early as Week 1."

The primary endpoint of the study was superiority for Taltz compared to TREMFYA in the proportion of patients achieving complete skin clearance as measured by PASI 100 at Week 12. Key secondary endpoints included superiority over TREMFYA in the proportion of patients achieving PASI 75 at Week 2, PASI 90 at Weeks 4 and 8, PASI 100 at Weeks 4, 8 and 24, static Physician's Global Assessment (sPGA) 0 at Week 12 and PASI 50 at Week 1.

Patients treated with Taltz demonstrated statistically significantly higher improvements than those treated with TREMFYA as measured by PASI 100 at Week 12 (41.3 percent versus 24.9 percent, P<0.001). Additionally, all major secondary endpoints up to Week 12 were achieved (P<0.001).

"As new medicines become available for people living with psoriasis, there's an increasing need to directly compare the efficacy and safety of these treatments to help healthcare providers and patients make informed treatment decisions," said Rhonda Pacheco, Pharm.D., global brand development leader for immunology at Lilly. "These results demonstrate that Taltz can provide high levels of skin clearance early in treatment for people with psoriasis."

A total of 1,027 patients with moderate to severe plaque psoriasis were enrolled in the study to evaluate the efficacy and safety of Taltz compared to TREMFYA. Participants were randomized to receive Taltz or TREMFYA at the approved dose for a total of 24 weeks, with the primary analysis conducted at 12 weeks.

In IXORA-R, the safety profiles of Taltz and TREMFYA were consistent with those previously reported for both treatments. As the IXORA-R study is ongoing, not all data will be presented at this meeting to prevent unblinding for investigators and participants. Lilly plans to share results on the remaining key secondary endpoint of proportion of patients achieving PASI 100 at 24 weeks in 2020.

Source: lilly.com

Taltz (ixekizumab)

Tremfya (guselkumab)

[Caroline]

Hihi Competition.... now lower the prices...