Skilerence - skin looks worse

[jiml]

Thanks for the warm welcome. I guess I’m just having a flare up.  I will keep you all up to date though. X

Hopefully it will pass quickly and the Skilarence will start to show results, I don't know how long you have suffered with psoriasis before being put on skilarence or what other treatments you have tried.  But know in all the many years I've suffered with psoriasis this is the only thing that has given me any long term clearance . So my advice is be patient, which is easier said than done.

Jim 

Ive had psoriasis since I was 13yrs and I’m now 43yrs. I’ve tried everything.  Before this I was on Methotrexate which did nothing. Now I’ve finished having children it’s time for the big guns.  Fingers crossed it works.

That's good that you got skilarence the dermalogists seem to favour methotrexate first every time I hope you get the same success that I have had and there's no reason why it shouldn't work well and save the biological drugs for much later
I first had psoriasis at age 17 and had fought it all my adult life I'm 72 now and the last 7 years have been the best years for me barely thinking about psoriasis and living life to the full

[Kerry181175]

Skilarence update.  I’m now into week six and currently taken 3 x 120mg, 1 in the morning and 2 in the evening.  Symptoms so far have been a burning sensation starting on my head first and then moves to my arms and chest.  It doesn’t last long (around 20mins) but can be itchy.  Have not yet experienced any other thank god.  Let’s hope it stay this way.  I haven’t seen any improvement in my skin yet   but you have said it can take a few weeks so fingers crossed something happens soon.  X

[Caroline]

Skilarence update.  I’m now into week six and currently taken 3 x 120mg, 1 in the morning and 2 in the evening.  Symptoms so far have been a burning sensation starting on my head first and then moves to my arms and chest.  It doesn’t last long (around 20mins) but can be itchy.  Have not yet experienced any other thank god.  Let’s hope it stay this way.  I haven’t seen any improvement in my skin yet   but you have said it can take a few weeks so fingers crossed something happens soon.  X

Hi Kerry,

Yes, that is a common flush. I have had that, and sometimes still have, also, even being completely red. I do not experience it as itchy though.
No big deal and the most harmless side effect. The advantage of having a flush is the fact that is seems that your body reacts to the DMF. That is a positive sign.

Keep on going !,

Caroline

[jiml]

Great news you are having flushes Kerry    it is a sign that it's starting to work on you. I hope soon you will start to see improvement in your skin, but you might need to get to full dose first ....but hopefully not as you are getting side effects 
Stick with it the long term benefits will be worth the wait 

[Kerry181175]

Skilarence update.  I’m now into week six and currently taken 3 x 120mg, 1 in the morning and 2 in the evening.  Symptoms so far have been a burning sensation starting on my head first and then moves to my arms and chest.  It doesn’t last long (around 20mins) but can be itchy.  Have not yet experienced any other thank god.  Let’s hope it stay this way.  I haven’t seen any improvement in my skin yet   but you have said it can take a few weeks so fingers crossed something happens soon.  X

Hi Kerry,

Yes, that is a common flush. I have had that, and sometimes still have, also, even being completely red. I do not experience it as itchy though.
No big deal and the most harmless side effect. The advantage of having a flush is the fact that is seems that your body reacts to the DMF. That is a positive sign.

Keep on going !, 

Caroline

Thanks Caroline, that’s good to know. Hope it continues to work. X

[Kerry181175]

Update - halfway through week six and skin does not look any different. My skin is very dry and my plaques are the same.  I don’t see any improvement yet. ?

[Fred]

Update - halfway through week six and skin does not look any different. My skin is very dry and my plaques are the same.  I don’t see any improvement yet. ?

I'm not sure about Skilarence, but usually 12 weeks is when you should of seen some improvement with most other treatments.

Good luck, Kerry.

[jiml]

It's frustrating Kerry when it takes time to kick in I know, and depressing when you just want to be rid of the plaques. Is it next week you start on 6 tablets a day ?
I would stay positive now and I'm hopeful you will begin to see results in the next week or two ...
I'm really willing this to work for you as it's such a safe drug and can keep you clear for years when it does work
Good luck and thanks for the updates
Jim

[Kerry181175]

It's frustrating Kerry when it takes time to kick in I know, and depressing when you just want to be rid of the plaques. Is it next week you start on 6 tablets a day ? 
I would stay positive now and I'm hopeful you will begin to see results in the next week or two ...
I'm really willing this to work for you as it's such a safe drug and can keep you clear for years when it does work
Good luck and thanks for the updates
Jim

Thanks Jim 

It is really frustrating as it covers most of my body ? so I am desperate for it work. 
I’m currently taking 3 x 120mg. My consultant did say to me that if my side effects were mild after upping my dose I should increase again it earlier than the next week.  Bit nervous about that though.
Any thoughts? 
Kerry

[Caroline]

It's frustrating Kerry when it takes time to kick in I know, and depressing when you just want to be rid of the plaques. Is it next week you start on 6 tablets a day ? 
I would stay positive now and I'm hopeful you will begin to see results in the next week or two ...
I'm really willing this to work for you as it's such a safe drug and can keep you clear for years when it does work
Good luck and thanks for the updates
Jim

Thanks Jim 

It is really frustrating as it covers most of my body ? so I am desperate for it work. 
I’m currently taking 3 x 120mg. My consultant did say to me that if my side effects were mild after upping my dose I should increase again it earlier than the next week.  Bit nervous about that though.
Any thoughts? 
Kerry

Yes, my thought is not to increase too fast. Stick to the schedule that is prescribed in the accompanying flyer.
If you move up too fast, your lymphocytes may go down to deep. You don’t want that. Because then you will have to stop with the treatment and imagine that it might start working in a few weeks.
By gradually upping the dose, you keep your lymphos on a good level.
That is why people with MS who start with tecfidera, often bump into lymphoma (too low levels) as the scheme over there is way to fast.
Not faster than an increase of 1 pill per week, preferably even slower.