Psoriasis is associated with long‐term risk for overall malignancy in Koreans

[Fred]

This study looked at the long term risk of malignancy in Korean adult patients with psoriasis.

Quote:

---

Background:
The association between psoriasis and risk of malignancy has not been thoroughly evaluated in a large longitudinal cohort of Asian population.

Objective:
To determine the long‐term risk of malignancy in Korean adult patients with psoriasis.

Methods:
We conducted a nationwide population‐based prospective cohort study with a 15‐year observational period. During the baseline period (1997‐2000), total 1,773,786 Korean subjects who received health insurance from the National Health Insurance System were enrolled and 5,788 subjects were defined as a psoriasis group. The number of new‐onset malignancy was collected during the observational period (2001‐2015).

Results:
Patients with psoriasis had a higher adjusted hazard ratio (aHR) for development of overall malignancy (aHR 1.08, 95% confidence interval [CI] 1.00‐1.18) and gastric cancer (aHR 1.31, 95% CI 1.08‐1.58) compared to controls. The risks of non‐Hodgkin lymphoma and non‐melanoma skin cancer were significantly increased only in patients with psoriasis who received systemic treatments (aHR 2.86, 95% CI 1.07‐7.61 and aHR 3.93, 95% CI 1.47‐10.47, respectively).

Conclusion:
Psoriasis is associated with long‐term risk for overall malignancy in Koreans, which was primarily driven by the increased risk of gastric cancer.

Source: onlinelibrary.wiley.com

*Early view funding unknown

[jiml]

Am I reading it right that it's not the psoriasis that causes the increased risk it's the systemic treatments.

[Caroline]

Am I reading it right that it's not the psoriasis that causes the increased risk it's the systemic treatments.

Seems so yes
We would need the full report to check everything and to verify the hypothesis

[D Foster]

Am I reading it right that it's not the psoriasis that causes the increased risk it's the systemic treatments.

Seems so yes
We would need the full report to check everything and to verify the hypothesis

Or the kimchi.