Injecting near the psoriasis any benefits ?

[Fred]

As far as I understand it the Bio is absorbed under the skin slowly and spread around the body over a period of time, but could it help psoriasis better or quicker if it was injected nearer to the psoriasis ?

I always inject in the belly, but today I have injected in my legs as that is where Cosentyx seems to be struggling. I doubt it will make any difference but thought it may be worth a try.

I know you should never inject directly into the psoriasis but does anyone have any thoughts on if there are indeed any benefits of injecting nearer the site of the problem  ?

[jiml]

Can’t help there as never been on an injectable drug, but I see your logic in trying it. You have nothing to lose with that sort of experimenting and could actually make a difference
Good luck

[Caroline]

I don’t think it would make a difference. Or maybe it does, but even contraproductive.
The injections with the bio, are aiming at the cells in your body. All cells, as it is not possible to go for specific cells. In that cells e.g. consentyx blocks Il-17, which in its turn reduces the activity of the cell in your arthritis or your Psoriasis.
The Psoriasis, the increased cell replication, gets to a hold from the inside, as it is only a representant of the immune disease you have which is everywhere in your body.

If you inject it, subcutaneous into a Psoriasis spot, it might get stuck more or less in the dead tissue that Psoriasis is and it might not spread effectively to your cells.

[Fred]

I don’t think it would make a difference. Or maybe it does, but even contraproductive.
The injections with the bio, are aiming at the cells in your body. All cells, as it is not possible to go for specific cells. In that cells e.g. consentyx blocks Il-17, which in its turn reduces the activity of the cell in your arthritis or your Psoriasis.
The Psoriasis, the increased cell replication, gets to a hold from the inside, as it is only a representant of the immune disease you have which is everywhere in your body.

If you inject it, subcutaneous into a Psoriasis spot, it might get stuck more or less in the dead tissue that Psoriasis is and it might not spread effectively to your cells.

No I wouldn't inject into the psoriasis, that is a big  No No  

As a point of interest you inject in your groin with your treatment I wonder why that is the chosen route ?

@Jim thank you.

[Caroline]

I don’t think it would make a difference. Or maybe it does, but even contraproductive.
The injections with the bio, are aiming at the cells in your body. All cells, as it is not possible to go for specific cells. In that cells e.g. consentyx blocks Il-17, which in its turn reduces the activity of the cell in your arthritis or your Psoriasis.
The Psoriasis, the increased cell replication, gets to a hold from the inside, as it is only a representant of the immune disease you have which is everywhere in your body.

If you inject it, subcutaneous into a Psoriasis spot, it might get stuck more or less in the dead tissue that Psoriasis is and it might not spread effectively to your cells.

No I wouldn't inject into the psoriasis, that is a big  No No  

As a point of interest you inject in your groin with your treatment I wonder why that is the chosen route ?

@Jim thank you.

The reason for that location is that the now visible DNA that is in the blood has to be taken to the production center of the T-helper cells. That is to be done by the lymphe system.
There is a concentration of lymphe access buttons under your arms and in your groin.
Injecting under your arm is bit more risk full as there are large veins also under your arm, in you groin also, but over there they are much deeper and that is much more space to just go under the skin.

Basically you can give the injections everywhere, but in the end, to start working it has to access the lymph system. If you would inject it in your belly for instance, then it would take much much longer to reach the lymphe system. Then even the muscle would be a better place as more blood runs though that, or subcutaneous close to a muscle in a non-fat area.

[Fred]

The reason for that location is that the now visible DNA that is in the blood has to be taken to the production center of the T-helper cells. That is to be done by the lymphe system.
There is a concentration of lymphe access buttons under your arms and in your groin.
Injecting under your arm is bit more risk full as there are large veins also under your arm

Interesting, I understand the lymph access buttons as you say but now you have me thinking.

#1 Is it best to inject a Bio near the psoriasis.

#2 Is it best to inject it near a Lymph.

#3 Or it makes no difference where you inject a Bio as long as it is within the recommended sites

[Caroline]

The reason for that location is that the now visible DNA that is in the blood has to be taken to the production center of the T-helper cells. That is to be done by the lymphe system.
There is a concentration of lymphe access buttons under your arms and in your groin.
Injecting under your arm is bit more risk full as there are large veins also under your arm

Interesting, I understand the lymph access buttons as you say but now you have me thinking.

#1 Is it best to inject a Bio near the psoriasis.

#2 Is it best to inject it near a Lymph.

#3 Or it makes no difference where you inject a Bio as long as it is within the recommended sites

I am guessing it would be #3.
For me, see my earlier post, #1 would make no specific sense, as I think the location is not relevant.
#2 also makes no sense to me. You are not trying to learn the immune system something, like I am doing with the autovaccin therapy, you are targeting cells in your body to be less sensitive or better blocking at all one of its receptors.
It might even be #4 A place where the bio can stay and will gradually be absorbed by your body, and probably those are the recommended sites. I think the belly, with its fat layer would be excellent.

[Bill]

It might be useful to think of why it might help. Cosentyx is an antibody which binds to the il-17a protein. I found an article on psoriasis which looks at the thus far implicated cell populations.

<New insights of T cells in the pathogenesis of psoriasis>

Nice to see a complete article instead of an abstract. I'd try it just for the hell of it. I don't see a big risk.

Cheers