IL-23 a potential target for psoriasis treatment

[Fred]

This study suggests that targeting IL-23 alone could be a potential treatment for psoriasis.

Quote:

---

Background:
The development of monoclonal antibodies targeting IL-12 and IL-23 has enhanced the therapeutic options available for psoriasis patients. Recent research suggests that IL-23 alone plays a role in the pathogenesis of psoriasis.

Objective:
The objective was to review the phase III clinical trial data for the anti-IL-23 agents in order to evaluate the safety and efficacy profile of each agent.

Methods:
We reviewed the results of the phase III clinical trials for the anti-IL-23 agents tildrakizumab and guselkumab. The results of phase III trials on risankizumab have not yet been reported.

Results:
By week 12, the proportion of patients reaching Psoriasis Area and Severity Index (PASI 75) was greater than 60% among the most efficacious dose of each agent. The percentage of patients achieving PASI 90 at week 16 was the primary endpoint for the phase III trials for guselkumab, which was above 70%. The safety profiles of the agents were comparable, with the most commonly reported adverse events of nasopharyngitis and upper respiratory tract infections.

Conclusion:
The anti-IL-23 agents demonstrated a rapid clinical improvement that is similar or superior to the improvement seen with currently marketed IL-17 inhibitors with a favorable short-term safety profile. The results of the phase III trials support the notion that IL-23 is a potential target in psoriasis treatment.

Source: onlinelibrary.wiley.com

*Early view funding unknown

[Caroline]

Makes common sense. Even quite logical. Stelara is working very well against Psoriasis and is an IL-23 inhibitor. I had expected that this research would have been excuted already long ago in advance of the development of Stelara. Read an article over here in NL, that has this suggestion also on the basis of other research.