Psoriasis comorbidity and multiple sclerosis progression study

[Fred]

This study assess whether psoriasis comorbidity affected the progression of multiple sclerosis (MS)

Quote:

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Background:
Multiple sclerosis (MS) and psoriasis are inflammatory disorders, with epidemiological and biological associations. The impact of one disease on the course of the other has not been studied.

Objective:
To characterize patients with psoriasis and MS, and to assess whether psoriasis comorbidity affected the progression of MS.

Methods:
A retrospective case control study. Patients with psoriasis comorbidity were identified from 3456 patients included in the Sheba Hospital Multiple Sclerosis Center database. Clinical and demographical characteristics and MS progression-related outcomes in patients whose follow up exceeded 5 years were analyzed and compared to those of a matched control cohort of MS-only (MSO) patients.

Results:
Forty-five (1.3%) MS patients had psoriasis comorbidity. Psoriasis preceded MS in thirty-five (78%) cases. The psoriasis was defined as mild, moderate, and severe in twenty-four (53%), twelve (27%), and nine (20%) cases, respectively. MS progression-related outcomes were evaluated in 35 patients that had follow-up over 5 years. Patients with psoriasis onset preceding relapsing-remitting MS (RRMS) had slower progression of disease compared to MSO patients, as manifested by a longer time to second relapse (p<0.01) and a longer time to significant neurological disability scores (p<0.03).

Conclusion:
Psoriasis comorbidity preceding the onset of MS is associated with slower progression of disability.

Source: onlinelibrary.wiley.com

*Early view funding unknown.

[Caroline]

This study assess whether psoriasis comorbidity affected the progression of multiple sclerosis (MS)

Quote:

---

Background:
Multiple sclerosis (MS) and psoriasis are inflammatory disorders, with epidemiological and biological associations. The impact of one disease on the course of the other has not been studied.

Objective:
To characterize patients with psoriasis and MS, and to assess whether psoriasis comorbidity affected the progression of MS.

Methods:
A retrospective case control study. Patients with psoriasis comorbidity were identified from 3456 patients included in the Sheba Hospital Multiple Sclerosis Center database. Clinical and demographical characteristics and MS progression-related outcomes in patients whose follow up exceeded 5 years were analyzed and compared to those of a matched control cohort of MS-only (MSO) patients.

Results:
Forty-five (1.3%) MS patients had psoriasis comorbidity. Psoriasis preceded MS in thirty-five (78%) cases. The psoriasis was defined as mild, moderate, and severe in twenty-four (53%), twelve (27%), and nine (20%) cases, respectively. MS progression-related outcomes were evaluated in 35 patients that had follow-up over 5 years. Patients with psoriasis onset preceding relapsing-remitting MS (RRMS) had slower progression of disease compared to MSO patients, as manifested by a longer time to second relapse (p<0.01) and a longer time to significant neurological disability scores (p<0.03).

Conclusion:
Psoriasis comorbidity preceding the onset of MS is associated with slower progression of disability.

Source: onlinelibrary.wiley.com

*Early view funding unknown.

I need to do some calculations, as I don't seem to get the numbers.

We start with 3456 (amazing number) patiënts.

45 ( 45/34,56 = 1.3%) MS had Psoriasis comorbidity (= simultaneous presence).
Psoriasis Preceded MS in 35 cases, 78%.... O.... 35/.45 = 77.77%  This is 35/34.56 = 1% of the total number of patients.

The mild, moderate and severe numbers add up to 100%  But if you look at the total number of patients
.53 % had mild
.27 % had moderate and
.2 % had severe psoriasis.
Isn't this about normal in the whole population?

The MS patients were 'lucky' when they also had psoriasis, as this slowed down the progress of their MS. Though this last conclusion has nothing to do with the given numbers.

I think I get it now.