Could Cosentyx be better than first thought for psoriasis

[Fred]

Novartis say that new results show that Cosentyx not only treats psoriasis but can also modify it's course, and have initiated a new trial to assess early intervention in new onset psoriasis with the aim of giving long term clearance.

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Novartis today announced new data suggesting, for the first time, that Cosentyx® (secukinumab) may modify the course of moderate-to-severe psoriasis leading to long-term, treatment-free skin clearance. Cosentyx is the first and only IL-17A inhibitor to have reported this potential of disease modification. These data were presented at the 13th Annual Maui Derm for Dermatologists 2017, Maui, Hawaii at which Novartis presented 14 abstracts.

Following one year of treatment with Cosentyx, patients were randomized to either continuous treatment or treatment cessation until relapse. Patients with continuous treatment maintained their high level of response. Among the patients that discontinued treatment, 21% of psoriasis patients maintained skin clearance for up to one year without treatment and 10% maintained skin clearance after two years without treatment. Patients with longer disease duration were more likely to relapse, suggesting that early intervention increases the chance of remaining relapse free.

Previous data has shown that Cosentyx, a fully human, specific inhibitor of the IL-17A cytokine, delivers long-lasting clear or almost clear skin (PASI 90 to PASI 100) in up to 80% of patients out to four years.

"These results suggest that Cosentyx may go beyond simply treating symptoms and could actually modify the course of psoriasis, and highlights the need for further investigation into early intervention," said Vas Narasimhan, Global Head, Drug Development and Chief Medical Officer, Novartis. "Being able to change the course of disease is the ultimate goal of treatment, which is why we are investing in the STEPIn trial to further understand the disease modifying ability of Cosentyx in psoriasis."

This is the first robust long-term data on psoriasis following treatment discontinuation. These data (from extension study A2302E1) show low scores on the Psoriasis Area Severity Index (PASI) were maintained after treatment discontinuation following one year on Cosentyx (PASI score of 2.9 after 1 year and 1.7 after 2 years off-drug, vs. 20.5 and 19.2 at Baseline). Additionally, of the 120 patients who were PASI 75 responders and switched to placebo at one year, 21% remained relapse-free after one year and 10% were relapse-free after two years off-treatment. Patients who had a longer disease duration before Cosentyx treatment were more likely to relapse, highlighting the potential importance of early treatment. To further investigate the disease modification potential of Cosentyx, Novartis has initiated the STEPIn trial to assess early intervention with Cosentyx in new-onset disease. The ambition is to identify a novel strategy of treating patients with new-onset moderate-to-severe psoriasis, by providing evidence to inform the use of early treatment.

Source: novartis .com

[jiml]

That's great to read ... although I feel it will fall on deaf ears and dermatologists will still go through their list of treatments before getting to cosentyx . It would be great if new sufferers were prescribed it as soon as they were diagnosed. If it actually modifies the disease and can hold psoriasis back even when treatment ends

[Fred]

That's great to read ... although I feel it will fall on deaf ears and dermatologists will still go through their list of treatments before getting to cosentyx . It would be great if new sufferers were prescribed it as soon as they were diagnosed. If it actually modifies the disease and can hold psoriasis back even when treatment ends

Yes I think it will take time. But imagine how much it could save if they gave say a years worth of Cosentyx at early onset and a patient was clear for say 5 - 10 years or even for good. Not only in treatment cost but also in lost work time and peoples social spending.

[Caroline]

That's great to read ... although I feel it will fall on deaf ears and dermatologists will still go through their list of treatments before getting to cosentyx . It would be great if new sufferers were prescribed it as soon as they were diagnosed. If it actually modifies the disease and can hold psoriasis back even when treatment ends

Yes I think it will take time. But imagine how much it could save if they gave say a years worth of Cosentyx at early onset and a patient was clear for say 5 - 10 years or even for good. Not only in treatment cost but also in lost work time and peoples social spending.

Yes, would be great savings, and a great good for the patients.

I have heard before that they were experimenting with the approach of trying to hit the disease in the beginning stadium very hard, which they have very good results with. I think I read it in a rheuma context.
But this would need you to be in an academical hospital, where they are open for those type of approaches. I fear the in the normal hospital, they will follow the old-fashioned guidelines. Just like Jim says.

[jiml]

Yes Fred and Caroline I agree but it needs a different approach from dermatologists, who hopefully will accept this and other studies, given enough time and publicity to the fact that an expensive treatment could be very beneficial in the early stages of psoriasis, by modifying the course of psoriasis, By inhibiting the disease for the foreseeable future could in fact save health services and insurers vast amounts of money in the future. And also have a positive effect on sufferers who's self esteem will be lifted quickly ....instead of suffering with various creams and tablets for years masking the disease with limited success

[Bill]

Dare I mention it, but hasn't DMF done the same for some patients?

Cheers,

Bill

[Fred]

Dare I mention it, but hasn't DMF done the same for some patients?

Cheers,

Bill

Yes you can mention it. But try to keep On Topic or start a new thread please Bill.

[Caroline]

Dare I mention it, but hasn't DMF done the same for some patients?

Cheers,

Bill