Taltz improves fingernail psoriasis

[Fred]

This study shows that Taltz (ixekizumab) gave significant improvements in fingernail psoriasis.

Quote:

---

Background:
Fingernail psoriasis is difficult to treat.

Objective:
The objective was to evaluate the effect of ixekizumab, a monoclonal antibody selectively targeting IL-17A, on fingernail psoriasis.

Methods:
This Phase 3, double-blind trial (UNCOVER-3) randomized patients to placebo, etanercept (50-mg twice weekly), or 80 mg ixekizumab as one injection every 4 (IXE Q4W) or 2 weeks (IXE Q2W) after a 160-mg starting dose. At Week 12, ixekizumab patients received open-label IXE Q4W through Week 60; placebo patients received a 160-mg starting ixekizumab dose and etanercept patients a 4-week placebo washout before starting IXE Q4W. Efficacy was assessed by mean per cent Nail Psoriasis Severity Index (NAPSI) improvement at Weeks 12 and 60.

Results:
Of 1346 patients in the UNCOVER-3 trial, this subgroup analysis included only patients with baseline fingernail psoriasis: 116 (60.1%) placebo, 236 (61.8%) etanercept, 228 (59.1%) IXE Q4W and 229 (59.5%) IXE Q2W. At Week 12, greater mean per cent NAPSI improvements were achieved in IXE Q4W (36.7%) and IXE Q2W (35.2%) vs. placebo (−34.3%, P < 0.001 each comparison) and etanercept (20.0%, P = 0.048 vs. Q4W, P = 0.072 vs. Q2W). At Week 60, mean per cent NAPSI improvement was >80% regardless of initial treatment. At Week 12 (nonresponder imputation), complete resolution (NAPSI = 0) was achieved in 19.7% (IXE Q4W), 17.5% (IXE Q2W), 4.3% (placebo, P < 0.001 each comparison) and 10.2% (etanercept, P < 0.05 each comparison) of patients. By Week 60, >50% of patients achieved complete resolution.

Conclusions:
At Week 12, significant improvements in fingernail psoriasis were achieved with ixekizumab therapy. With IXE Q4W maintenance dosing, additional improvement was demonstrated through 60 weeks, and >50% of patients achieved complete resolution.

Source: onlinelibrary.wiley.com

*Funding: Eli Lilly

[Group Specific]

[Grizzly Bear]

Seems that this Taltz is rather good.

[Fred]

Seems that this Taltz is rather good.  

Yes it looks like Cosentyx and Taltz have a fight on. They are both showing excellent results, and it's going to be interesting to see which one comes out top as they are both targeting the same thing.

What I've read so far, my money is on Taltz winning this one.

[Grizzly Bear]

Is this Cosentyx injection or tablets Fred ?

If my stelara fails some time in the future, I hope that the new dermatologist at taunton gives me Cosentyx or Taltz

[Fred]

Is this Cosentyx injection or tablets Fred ?

If my stelara fails some time in the future, I hope that the new dermatologist at taunton gives me Cosentyx or Taltz  

Injection Andy. I don't do tablets

The maintenance dose is two shots every month.