Cyclosporin could be safe with pregnancy

[Fred]

This study suggests that Cyclosporin could be safe when pregnancy occurs.

Quote:

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Problem:
Cyclosporin A (CYS A) is an immunosuppressant agent administered in autoimmune diseases, and its use during pregnancy and lactation is a debated topic.

Method of study:
The demographic characteristics, the activity of the underlying disease, and the onset of fetal–maternal complications have been investigated in 21 consecutive patients (2 RA, 14 SLE, 2 PA, 1 SjS, 1 DM, 1 Churg–Strauss vasculitis), treated with CYS A throughout 29 gestations. A subanalysis of the SLE group was performed.

Results:
We recorded a live birth rate of 86.2%. The median gestational age at birth was 38.2 weeks. The prevalence of maternal–fetal complications showed no differences with general population. Disease flares appeared in 4% of patients during gestation and in 12% during puerperium.

Conclusion:
We found no evidence justifying the suspension of CYS A when a pregnancy occurs. The drug does not appear to promote maternal–fetal complications and should be continued in patients who benefit from therapy. Data regarding breast-feeding during therapy are still scarce, but no evidence of toxicity has emerged.

Source: onlinelibrary.wiley.com

*Early view funding unknown.

Ciclosporine

[Caroline]

That is the last thing I will believe. (Just an emotional reaction )

[Fred]

 
That is the last thing I will believe. (Just an emotional reaction )

I'm with you on that one. Personally I would advise anyone Male and Female if you are thinking of pregnancy to forget any pills or injections used to treat psoriasis, and also be very careful with the creams too.

In other words if you want to have a Baby you could try modifying your diet and/or lifestyle (though I doubt that will work) put up with the psoriasis and give Baby a good start without any modifications.

That also goes for Smoking, Drinking, and All drugs both Recreational and Prescribed. Give the little thing a chance and let it decide when it's old enough what is best.

[Caroline]

 
That is the last thing I will believe. (Just an emotional reaction )

I'm with you on that one. Personally I would advise anyone Male and Female if you are thinking of pregnancy to forget any pills or injections used to treat psoriasis, and also be very careful with the creams too.

In other words if you want to have a Baby you could try modifying your diet and/or lifestyle (though I doubt that will work) put up with the psoriasis and give Baby a good start without any modifications.

That also goes for Smoking, Drinking, and All drugs both Recreational and Prescribed. Give the little thing a chance and let it decide when it's old enough what is best.

Jup We agree !!!

If I read around on the net, when searching for toxity of cyclosporine, then I read a lot of things that would not make me feel comfortable if I were pregnant. The number of possible side effects seems to be endless.

[Fred]

Jup We agree !!!

Should we have Fireworks to celebrate ?

[mataribot]

I think you guys summed this one well. I am kind of shocked they even have the guts to recommend this with all complications with High Blood Pressure and pregnancy. This drug boils your blood.

[Grizzly Bear]

This drug boils your blood.

I wonder if it can boil water to make a cup of tea ?