Skin cancer and psoriasis

[Fred]

This large Danish cohort study looked at the risk of new-onset melanoma and non-melanoma skin cancer (NMSC) in patients with psoriasis and psoriatic arthritis.

Quote:

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Background:
Psoriasis is a chronic inflammatory skin disease that is commonly treated with ultraviolet phototherapy and systemic immunosuppressant drugs, which may confer a risk of skin cancer. Previous studies on the risk of skin cancer in patients with psoriasis have shown conflicting results.

Objectives:
We investigated the risk of new-onset melanoma and non-melanoma skin cancer (NMSC), respectively, in a large cohort of patients with psoriasis and psoriatic arthritis.

Methods:
Data on all Danish individuals aged ≥18 years between 1 January 1997 and 31 December 2012 were linked at individual-level in nationwide registers. Incidence rates per 10 000 person-years were calculated, and incidence rate ratios (IRRs) were estimated by Poisson regression models.

Results:
The study comprised 5 559 420 individuals with a maximum follow-up time of 16 years. There were 75 410 patients with psoriasis, and 25 087 and 58 051 individuals developed melanoma and NMSC, respectively, during follow-up. Adjusted IRRs (95% CI) of melanoma were 1.19 (1.03–1.37), 1.09 (0.75–1.58) and 1.36 (0.94–1.99), in mild psoriasis, severe psoriasis and psoriatic arthritis, respectively, and the corresponding adjusted IRRs of NMSC were 1.67 (1.55–1.81), 1.32 (1.10–1.59) and 1.62 (1.27–2.05) respectively.

Conclusions:
We observed a modestly increased risk of melanoma and NMSC in patients with mild psoriasis, whereas patients with severe psoriasis and psoriatic arthritis had increased risk of NMSC but not melanoma. While the risk of skin cancer is only modestly increased in patients with psoriasis, clinicians should remain vigilant.

Source: onlinelibrary.wiley.com

Funded By: Pfizer

[jiml]

I would suspect the higher incidence of skin cancers in more severe cases of psoriasis were possibly due to UV treatments and the fact in my case that I expose my skin to the sun at every opportunity to try to rid myself of the disease...
It's a simplistic view of mine and I wonder if in the study they took account of treatments

[Caroline]

I would suspect the higher incidence of skin cancers in more severe cases of psoriasis were possibly due to UV treatments and the fact in my case that I expose my skin to the sun at every opportunity to try to rid myself of the disease...
It's a simplistic view of mine and I wonder if in the study they took account of treatments

Indeed, you cannot see a clear distinction between the UV treated ones, the systemic treated ones and the non treated ones.

[Fred]

I would suspect the higher incidence of skin cancers in more severe cases of psoriasis were possibly due to UV treatments and the fact in my case that I expose my skin to the sun at every opportunity to try to rid myself of the disease...
It's a simplistic view of mine and I wonder if in the study they took account of treatments

Indeed, you cannot see  a clear distinction between the UV treated ones, the systemic treated ones and the non treated ones.

Sorry but t's only an Abstract, you can pay €38 if you want to read the whole article.

[jiml]

I would suspect the higher incidence of skin cancers in more severe cases of psoriasis were possibly due to UV treatments and the fact in my case that I expose my skin to the sun at every opportunity to try to rid myself of the disease...
It's a simplistic view of mine and I wonder if in the study they took account of treatments

Indeed, you cannot see  a clear distinction between the UV treated ones, the systemic treated ones and the non treated ones.

Sorry but t's only an Abstract, you can pay €38 if you want to read the whole article.

No I'm happy with an Abstract

[Fred]

I would suspect the higher incidence of skin cancers in more severe cases of psoriasis were possibly due to UV treatments and the fact in my case that I expose my skin to the sun at every opportunity to try to rid myself of the disease...
It's a simplistic view of mine and I wonder if in the study they took account of treatments

Indeed, you cannot see  a clear distinction between the UV treated ones, the systemic treated ones and the non treated ones.

Sorry but t's only an Abstract, you can pay €38 if you want to read the whole article.

No I'm happy with an Abstract  

Good choice the full articles are never that much better, there is just more waffle.

[jiml]

I would suspect the higher incidence of skin cancers in more severe cases of psoriasis were possibly due to UV treatments and the fact in my case that I expose my skin to the sun at every opportunity to try to rid myself of the disease...
It's a simplistic view of mine and I wonder if in the study they took account of treatments

Indeed, you cannot see  a clear distinction between the UV treated ones, the systemic treated ones and the non treated ones.

Sorry but t's only an Abstract, you can pay €38 if you want to read the whole article.

No I'm happy with an Abstract  

Good choice the full articles are never that much better, there is just more waffle.  

And the conclusions will be the same

[Fred]

Indeed, you cannot see  a clear distinction between the UV treated ones, the systemic treated ones and the non treated ones.

Sorry but t's only an Abstract, you can pay €38 if you want to read the whole article.

No I'm happy with an Abstract  

Good choice the full articles are never that much better, there is just more waffle.  

And the conclusions will be the same  

Yep the Background, Objectives, Methods, Results and conclusions are the same, just a lot longer and in more detail. Sometimes it's just pages of graphs, but yes the final result is exactly the same.