Canada gets topical patch for psoriasis

[Fred]

Health Canada has approved Beteflam (betamethasone valerate topical patch), a novel, patent-protected treatment of mild to moderate plaque psoriasis of the elbows and knees for a maximum duration of 30 days in adult patients.

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Cipher Pharmaceuticals Inc. today nnounced that Health Canada has approved PrBeteflam™ (betamethasone valerate topical patch), a novel, patent-protected treatment of mild to moderate plaque psoriasis of the elbows and knees for a maximum duration of 30 days in adult patients.

"We are pleased to make Beteflam available as a valuable new treatment option to Canadian dermatologists and to the patients who suffer from this disease," said Shawn O'Brien, President and CEO of Cipher. "Psoriasis affects one million Canadians1 and can profoundly impact the quality of life for many patients. Once the product is launched in Q2 2016, Beteflam is expected to be our fourth marketed product in Canada behind Epuris®, Vaniqa®, and Actikerall™. With potentially six commercial products on the Canadian market by the end of 2016, we have multiple new near-term revenue streams as we work toward our goal of reaching $50 million in annual sales in our Canadian dermatology business."

Topical corticosteroids remain the primary treatment for steroid-responsive inflammatory skin diseases, including mild to moderate chronic plaque psoriasis. Occlusion with plastic film dressings is a widely accepted procedure to enhance their efficacy, especially in the treatment of psoriasis. Beteflam is a patch that is applied once daily to the affected region and may be cut to fit the particular size and shape of the psoriatic lesion thereby reducing potential contact of the steroid with healthy areas of skin.

Cipher licensed the Canadian rights to Beteflam from Institut Biochimique SA ("IBSA"). The efficacy and safety of Beteflam was demonstrated by two randomized, active-controlled studies involving 555 patients with mild-to-moderate chronic plaque psoriasis, of which 281 patients received Beteflam. The results of the clinical program demonstrated that the clinical efficacy of  Beteflam  was superior to that of  betamethasone valerate 0.1% cream and comparable to that of Dovobet 50 µg calcipotriol plus 0.5 mg betamethasone dipropionate ointment. The commonly reported adverse drug reactions that occurred in patients using Beteflam were skin and subcutaneous tissue disorders, occurring in < 5% of patients treated.

Source: cipherpharma.com

[jiml]

Sounds a good idea for mild psoriasis on just a few odd plaques, it is occlusion made easy I suppose and will keep the steroid just on the plaque not as present smeared over a wide area, causing more skin damage

[Fred]

Sounds a good idea for mild psoriasis on just a few odd plaques, it is occlusion made easy I suppose and will keep the steroid just on the plaque not as present smeared over a wide area, causing more skin damage

Yes like you say it will only be any good for those with just a few annoying patches, and it does say max 30 days. I don't know how long it would before you could use it again, but I can't see it being that good myself.

[D Foster]

Sounds a good idea for mild psoriasis on just a few odd plaques, it is occlusion made easy I suppose and will keep the steroid just on the plaque not as present smeared over a wide area, causing more skin damage

Yes like you say it will only be any good for those with just a few annoying patches, and it does say max 30 days. I don't know how long it would before you could use it again, but I can't see it being that good myself.

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

[Fred]

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

It was in Nano Letters March 2015

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Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

Source: acs.org

[D Foster]

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

It was in Nano Letters March 2015

Quote:

---

Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

Source: acs.org

The one I saw was a trial of a bio for psoriasis on patients in USA that is being done at this moment in time .

[Fred]

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

It was in Nano Letters March 2015

Quote:

---

Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

Source: acs.org

The one I saw was a trial of a bio for psoriasis on patients in USA that is being done at this moment in time  .

Yes that is the one Etanercept (Enbrel)

I would still prefer the needle though myself.

[D Foster]

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

It was in Nano Letters March 2015

Quote:

---

Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

Source: acs.org

The one I saw was a trial of a bio for psoriasis on patients in USA that is being done at this moment in time  .

Yes that is the one Etanercept (Enbrel)

I would still prefer the needle though myself.

A really good idea if it works as an injection transports the drug into the muscle and it would be far more effective in the skin surface.

[Fred]

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

It was in Nano Letters March 2015

Quote:

---

Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

Source: acs.org

The one I saw was a trial of a bio for psoriasis on patients in USA that is being done at this moment in time  .

Yes that is the one Etanercept (Enbrel)

I would still prefer the needle though myself.

A really good idea if it works as an injection transports the drug into the muscle and it would be far more effective in the skin surface.

I think we better stop Dave as we are going off topic and I don't want people to get confused on what the thread is about.