Cosentyx patients maintain clear or almost clear skin across 3 years

[Fred]

More good news for Cosentyx (secukinumab) after Novartis present new data showing that the majority of patients are able to maintain clear or almost clear skin with Cosentyx across 3 years.

Quote:

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Novartis announced today new late-breaking data demonstrating that Cosentyx (secukinumab) provides high levels of skin clearance and sustained efficacy in patients with moderate-to-severe plaque psoriasis while maintaining a favorable safety profile across three years. The results of this study - the longest Phase III Cosentyx trial conducted to-date - were presented at the 24th Annual Congress of the European Academy of Dermatology and Venereology (EADV) in Copenhagen, Denmark. Cosentyx is the first fully human interleukin-17A (IL-17A) inhibitor approved to treat adult moderate-to-severe plaque psoriasis.

In this extension study, 320 patients received Cosentyx in a fixed dosing schedule for three years. 69% achieved clear or almost clear skin (PASI 90) at year one. This response was extremely well maintained after three years with 64% of patients continuing to have a PASI 90 response. In addition, 43% of patients maintained completely clear skin (PASI 100) at year three (from 44% at year one). 83% achieved the standard treatment goal of PASI 75 skin clearance at three years.

"Psoriasis patients want therapies that maintain high levels of skin clearance over the long-term given the impact of the disease on their physical and psychological wellbeing," said Vasant Narasimhan, Global Head of Development, Novartis Pharmaceuticals. "In these new data from our longest Phase III trial to date with Cosentyx, we are pleased to show patients were able to maintain clear or almost clear skin for up to three years."

The PASI score assesses the reduction from baseline in the redness, scaling and thickness of psoriatic plaques and to what extent it affects each area of the body. PASI 75 has historically been considered the goal for psoriasis treatment. However, with newer treatments with increased efficacy, there is now a focus on PASI 90 (clear or almost clear skin) and PASI 100 (clear skin) as the ultimate goal for treatment, as recommended by clinical guidelines and regulatory authorities.

In this study, Cosentyx had a favorable safety profile consistent with that observed in previous Phase III studies.

Source: novartis.com

[jiml]

That is great news for sufferers it gives hope for the future. Cosentyx seems to be a good long term treatment for sufferers
It think if there was a good time to have to have psoriasis now is it ....
I know it's an awful disease to live with but with news like this coming out, it shows there are great advances being made

[Kat]

That is great news for sufferers it gives hope for the future. Cosentyx seems to be a good long term treatment for sufferers
It think if there was a good time to have to have psoriasis now is it ....
I know it's an awful disease to live with but with news like this coming out, it shows there are great advances being made

Advances yes... affordability not so much, at least in some areas. I do hope that improves as well.