Dimethyl fumarate data shows effectiveness in modulating Th17, Th1 & Th2

[Fred]

An interesting one for the DMF gang, this study looked at the effectiveness of Dimethyl Fumarate (DMF) in modulating the Th17, Th1 and Th2 helper cells. We have a lot of members using DMF in it's various forms (Fumaderm, Psorinovo, and even Bill using it raw) so I thought you may find this interesting.

Quote:

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Background:
Fumaric acid esters such as dimethyl fumarate (DMF) have proven to be effective in the treatment of psoriasis.

Objectives:
In view of the role of Th17 in the pathogenesis of psoriasis, the present study was conducted to investigate the effects of DMF on Th1, Th2, and Th17 responses in patients.

Methods:
Peripheral blood mononuclear cells (PBMCs) were isolated from psoriasis patients and healthy individuals and were cultured in the presence or absence of phytohemagglutinin and DMF. The cell supernatants were removed to measure cytokine secretion, and the lymphocytes were used for real-time polymerase chain reaction to establish gene expression.

Results:
An increase in gene expression of interferon-γ (IFN-γ), as a marker for Th1 activity, and interleukin-17 (IL-17), granulocyte macrophage colony-stimulating factor (GM-CSF) and IL-22 representing the Th17 subset in the PBMCs of patients in comparison with those of control subjects was observed. Culture of PBMCs from psoriasis patients and controls in the presence of DMF decreased IFN-γ and increased IL-4 gene expression in both groups. Treatment with DMF could significantly decrease IL-17, GM-CSF, and IL-22 mRNA levels in the PBMCs of patients. Decreased release of IFN-γ and GM-CSF cytokine secretion after DMF treatment was also observed in PBMC cultures of patients and controls.

Conclusions:
These data show the effectiveness of DMF in modulating Th17 cells in addition to Th1/Th2 cells and reflect one of the underlying mechanisms of action of DMF in psoriasis. These findings may also support the possible benefits of using fumarate in the treatment of other autoimmune diseases in the pathogeneses of which Th1 and Th17 cells play major roles.

Source: onlinelibrary.wiley.com

*Funding: Iranian National Science Foundation.

[jiml]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

[Caroline]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

Seems like an interesting study. Finally they seem to get to point of DMF in relation to auto immune diseases.

[Caroline]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

Seems like an interesting study. Finally they seem to get to point of DMF in relation to auto immune diseases.

By the way, if someone gets into a discussion with his derm, who apparently not knows of the existence of DMF, than seachr this article 274085952_Dimethyl_fumarate_in_relapsingremitting_multiple_sclerosis_rationale_mechanisms_of_action_pharmacokinetics_efficacy_and_safety/links/552d641b0cf2e089a3ad756c.pdf on Google as this article shows that DMF is already in use for more that 50 years for the treatment of Psoriasis.

[Fred]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

Seems like an interesting study. Finally they seem to get to point of DMF in relation to auto immune diseases.

By the way, if someone gets into a discussion with his derm, who apparently not knows of the existence of DMF, than seachr this article 274085952_Dimethyl_fumarate_in_relapsingremitting_multiple_sclerosis_rationale_mechanisms_of_action_pharmacokinetics_efficacy_and_safety/links/552d641b0cf2e089a3ad756c.pdf on Google as this article shows that DMF is already in use for more that 50 years for the treatment of Psoriasis.

Didn't work.

EDIT: Found it.

EDIT #2: I cant be bothered to read it, to long and boring.

[jiml]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

Seems like an interesting study. Finally they seem to get to point of DMF in relation to auto immune diseases.

By the way, if someone gets into a discussion with his derm, who apparently not knows of the existence of DMF, than seachr this article 274085952_Dimethyl_fumarate_in_relapsingremitting_multiple_sclerosis_rationale_mechanisms_of_action_pharmacokinetics_efficacy_and_safety/links/552d641b0cf2e089a3ad756c.pdf on Google as this article shows that DMF is already in use for more that 50 years for the treatment of Psoriasis.

I will have a look tonight and see if I can understand it

[Fred]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

Seems like an interesting study. Finally they seem to get to point of DMF in relation to auto immune diseases.

By the way, if someone gets into a discussion with his derm, who apparently not knows of the existence of DMF, than seachr this article 274085952_Dimethyl_fumarate_in_relapsingremitting_multiple_sclerosis_rationale_mechanisms_of_action_pharmacokinetics_efficacy_and_safety/links/552d641b0cf2e089a3ad756c.pdf on Google as this article shows that DMF is already in use for more that 50 years for the treatment of Psoriasis.

I will have a look tonight and see if I can understand it

Oh I can understand it and I found the mention of 50 years, but I was just saying I cant be bothered to read the rest as Caroline has already covered it very well here Dimethylfumarates and Psoriasis and I doubt there is much more in the article we don't already know about.

[jiml]

Aha a serious study of how DMF works, how interesting, may it spark a rash (excuse the pun) of further investigation  
Thanks Fred for reporting this

Seems like an interesting study. Finally they seem to get to point of DMF in relation to auto immune diseases.

By the way, if someone gets into a discussion with his derm, who apparently not knows of the existence of DMF, than seachr this article 274085952_Dimethyl_fumarate_in_relapsingremitting_multiple_sclerosis_rationale_mechanisms_of_action_pharmacokinetics_efficacy_and_safety/links/552d641b0cf2e089a3ad756c.pdf on Google as this article shows that DMF is already in use for more that 50 years for the treatment of Psoriasis.

I will have a look tonight and see if I can understand it

Oh I can understand it and I found the mention of 50 years, but I was just saying I cant be bothered to read the rest as Caroline has already covered it very well here Dimethylfumarates and Psoriasis and I doubt there is much more in the article we don't already know about.

I see but I will still have a look

[Fred]

I see but I will still have a look  

Oops sorry Jim I jumped the gun there, I thought you had answered my post but I now see it was Caroline's.