Psoriasis patients have higher risk of kidney disease

[Fred]

This study looked at the risk of kidney disease in people with psoriasis and psoriatic arthritis, it suggests they are at higher risk and that the use of Nonsteroidal anti-inflammatory drugs (NSAIDs) increases that risk.

Quote:

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Background:
Few studies have examined the association between psoriasis and glomerulonephritis (GN) as well as chronic kidney disease (CKD).

Objectives:
To determine the risk of CKD in patients with psoriasis and evaluate the impact of the severity of psoriasis, comorbidities, and concomitant medications on the risk of GN and CKD in patients with psoriasis.

Methods:
We identified 4344 patients with psoriasis for the study cohort and randomly selected 13032 subjects as a control cohort. Each subject was individually followed up for a 5-year period to identify those who subsequently developed GN and CKD.

Results:
After adjustment with traditional CKD risk factors, psoriasis was found to be independently associated with an increased risk of CKD during the 5-year follow-up period (hazard ratio (HR), 1.28; 95% confidence interval (CI), 1.14-1.44). The increased incidence GN in psoriasis patients (HR, 1.50; 95% CI, 1.24-1.81) may partly contributed to the positive association between psoriasis and CKD. Both patients with mild and severe psoriasis had an increased risk of CKD and GN compared with control cohort and the risk increased with severity. Psoriasis patients with arthritis exhibited a higher risk of CKD than patients without arthritis (HR, 1.62 vs. 1.26). Among medication, nonsteroidal anti-inflammatory drugs (NSAIDs) have the strongest association with CKD in patients with psoriasis (Adjusted Odds Ratio, 1.69; 95% CI, 1.14-2.49).

Conclusions:
Psoriasis was associated with a higher risk of developing CKD and GN. High severity, psoriatic arthritis involvement and concomitant NSAIDs use further increased the risk of CKD in patients with psoriasis.

Source: NO LINKS ALLOWED

*Early publication, no funding shown.

[Caroline]

Reading this and thinking of what I wrote yesterday evening, this very well might be correlated to the existence of the free radicals. See post RE: Dimethylfumarates and Psoriasis, for the theory on that.

[jiml]

So is this study saying its psoriasis that gives an increased risk of kidney disease.... Or is it the the drugs used to control psoriasis that cause the disease. I would imagine it's the latter its difficult to prove but the fact that the more severe the psoriasis .... The higher dose of drugs are used .... And a greater incidence of kidney disease... That's how I read it.

[Fred]

"Psoriasis was found to be independently associated with an increased risk"

"Psoriasis patients with arthritis exhibited a higher risk"

"Nonsteroidal anti-inflammatory drugs (NSAIDs) have the strongest association"

So the way I read it: We all have an increased risk, those with arthritis will have a higher risk. But those who use NSAIDs are at the highest risk overall.

[glenda grant]

So is this study saying its psoriasis that gives an increased risk of kidney disease.... Or is it the the drugs used to control psoriasis that cause the disease. I would imagine it's the latter its difficult to prove but the fact that the more severe the psoriasis .... The higher dose of drugs are used .... And a greater incidence of kidney disease... That's how I read it.

Jim I agree some of the meds and biologics could lead to kidney disease.I was told my kidneys are at 54% and i have to watch what kind of pills I take.I can only take tylenol and never more than two in one day.Never to take advil and such as they advertise on TV.Also my Dr told me i can never have radio-active dye could destroy my kidneys'I was reading that the psoriasis attacks our inside organs as well as our skin.I also have liver issues high liver count and have never been a drinker.Maybe i should start.This is such a horrible disease.I take a dose of 50 mg Enbrel every Sat.If I don't take it I can hardly walk.So it's do or die .