Higher rate of candidal colonization in patients with psoriasis

[Fred]

This study evaluated candidal colonization and specific humoral responses against Candida albicans in patients with psoriasis.

Candida is a genus of yeasts and is the most common cause of fungal infections worldwide. Candida albicans is the most commonly isolated species, and can cause infections (candidiasis or thrush)

Quote:

---

Background:
Psoriasis is an inflammatory skin disease that can considerably affect a patient's quality of life. Environmental and genetic factors, as well as superantigens and toxins from Candida species, may play various roles in the exacerbation and persistence of psoriasis. In the present study, we evaluated candidal colonization and specific humoral responses against Candida albicans in patients with psoriasis.

Methods:
A total of 100 patients with psoriasis vulgaris and 50 healthy control individuals were enrolled in the study. Skin and oral specimens from all participants were cultured on CHROMagar Candida medium. Isolated yeast-like fungi were identified using the sequence of the D1/D2 domain of the 26S rRNA gene. Enzyme-linked immunosorbent assays (ELISAs) were used to detect immunoglobulin M (IgM), IgA, and IgG antibodies against C. albicans in sera of patients and healthy individuals.

Results:
Candida species were isolated from the skin of 15% of patients and 4% of controls and from oral specimens of 60% of patients and 20% of controls. There was a significant difference in candidal colonization between patients and controls (P < 0.05). Serum IgM, IgA, and IgG levels against C. albicans were significantly lower in patients with psoriasis than in controls (P < 0.05). There was no significant association between serum levels of specific antibodies against C. albicans or the frequency of candidal colonization with the clinical severity of the disease (P > 0.05).

Conclusions:
The results of the present study show a higher rate of candidal colonization in patients with psoriasis in comparison with controls and a reduction in humoral immune responses in patients.

Source: onlinelibrary.wiley.com

[Bill]

Hi Fred,

As the abstract makes no mention of the treatments being used, I dont know what to make of the article. Candida albicans is a feature of immunosuppression, so finding it in elevated levels in patients taking immunosuppressive drugs would be expected. So what were the psoriasis patients being treated with?

Cheers,

Bill

[Fred]

Hi Fred,

As the abstract makes no mention of the treatments being used, I dont know what to make of the article. Candida albicans is a feature of immunosuppression, so finding it in elevated levels in patients taking immunosuppressive drugs would be expected. So what were the psoriasis patients being treated with?

Cheers,

Bill

Hello Bill, no the abstract doesn't mention any treatments and I don't know if the full article does either. It is available for purchase, but I purchased an article once and it wasn't worth the money. Once the full article is released in probably a month or so there may be more information, but if you do want to purchase it before then let me know and I will point you in the right direction to get it.

48 Hrs in read only mode: $6:00
PDF read/print/save for own use only: $35:00
*No reproduction allowed.

Regards.

Fred.

EDIT: I didn't mean Only as in Cheap, but for personal use Only.

[Bill]

Hi Fred,

I think I'd get a greater revelation from a few puffs of an electronic cigarette. No thanks.

Cheers,

Bill

[Fred]

Hi Fred,

I think I'd get a greater revelation from a few puffs of an electronic cigarette. No thanks.

Cheers,

Bill

I agree with you there bill, plus think how many doses of DMF you could get for $35:00

[Bill]

A tad under 3 years worth at my current dosage, Fred.

Cheers,

Bill