Biologic therapy ameliorates clinical symptoms of psoriasis

[Fred]

This study in The Journal of Dermatology showed that biologic therapy ameliorates clinical symptoms and controls the immune response in patients with psoriasis.

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Therapy with monoclonal antibodies to tumor necrosis factor (TNF)-α and the interleukin (IL)-12/23 p40 subunit has significantly improved the clinical outcome of patients with psoriasis. These antibodies inhibit the effects of the target cytokines and thus the major concern during their use is the induction of excessive immunosuppression.

Recent studies evaluating the long-term efficacy and safety of biologic therapy in psoriasis have shown no significant appearance of serious adverse effects including infections and malignancies. However, the immunological consequence and the mechanism by which the blockade of a single cytokine by biologics can successfully control the activity of psoriasis remain unclear.

In the current study, we investigated the effect of biologic therapy on cytokine production of various lymphocytes and on the activity of monocytes and neutrophils in psoriatic patients. Neutrophils, monocytes and T cells were purified from heparinized peripheral venous blood by Ficoll density gradient centrifugation, and γ-interferon, TNF-α and IL-17 production from lymphocytes was measured by flow cytometer. The activation maker of neutrophils and the activated subsets of monocytes were also analyzed.

Biologic therapy induced no significant changes in the cytokine production by lymphocytes from the skin and gut-homing T cells. However, neutrophil activity and the ratio of activated monocyte population increased in severely psoriatic patients were normalized in psoriatic patients receiving biologic therapy.

The present study showed that biologic therapy ameliorates clinical symptoms and controls the immune response in patients with psoriasis.

Source: NO LINKS ALLOWED

[jiml]

This study in The Journal of Dermatology showed that biologic therapy ameliorates clinical symptoms and controls the immune response in patients with psoriasis.

Quote:

---

Therapy with monoclonal antibodies to tumor necrosis factor (TNF)-α and the interleukin (IL)-12/23 p40 subunit has significantly improved the clinical outcome of patients with psoriasis. These antibodies inhibit the effects of the target cytokines and thus the major concern during their use is the induction of excessive immunosuppression.

Recent studies evaluating the long-term efficacy and safety of biologic therapy in psoriasis have shown no significant appearance of serious adverse effects including infections and malignancies. However, the immunological consequence and the mechanism by which the blockade of a single cytokine by biologics can successfully control the activity of psoriasis remain unclear.

In the current study, we investigated the effect of biologic therapy on cytokine production of various lymphocytes and on the activity of monocytes and neutrophils in psoriatic patients. Neutrophils, monocytes and T cells were purified from heparinized peripheral venous blood by Ficoll density gradient centrifugation, and γ-interferon, TNF-α and IL-17 production from lymphocytes was measured by flow cytometer. The activation maker of neutrophils and the activated subsets of monocytes were also analyzed.

Biologic therapy induced no significant changes in the cytokine production by lymphocytes from the skin and gut-homing T cells. However, neutrophil activity and the ratio of activated monocyte population increased in severely psoriatic patients were normalized in psoriatic patients receiving biologic therapy.

The present study showed that biologic therapy ameliorates clinical symptoms and controls the immune response in patients with psoriasis.

Source: NO LINKS ALLOWED

That's a big positive for biologicals, these studies are invaluable to dermatologists trying to prescribe useful treatments, and valuable to us as sufferers to take away some of the fears that surround these treatments.

Thanks for keep finding these studies Fred and posting them a great source of information

[Fred]

Thanks for keep finding these studies Fred and posting them a great source of information

You're welcome Jim, I'm glad it's helping. This thread has had 93 hits in one day so people are reading it.