Enbrel pattern of response

[Fred]

This study was published in The British Journal of Dermatology and looks at the pattern of response in patients with moderate-to-severe psoriasis treated with Enbrel (etanercept)

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Background:
Etanercept (ETN) 50 mg once-weekly (QW) or 50 mg twice-weekly (BIW) for 12 weeks, followed by 50 mg QW in all subjects through week 24 improved psoriasis in patients with concomitant psoriatic arthritis in the PRESTA trial. Data from PRESTA were used to evaluate the effect of ETN in the treatment of psoriasis by Psoriasis Area Severity Index (PASI) body-region and component, and determine if PASI responses correlate with the Dermatology Life Quality Index (DLQI).

Methods:
Median time to 75% improvement in PASI (PASI75), body-specific and component-specific subscales over 24 weeks was estimated. Pearson correlation coefficients determined the association between DLQI score and PASI total score, body- and component-specific subscales with ETN treatment at baseline and up to Week 24.

Results:
748 patients from PRESTA were included (ETN 50 mg QW/QW, n = 371; BIW/QW, n = 377). Patients achieved PASI75 total score and 75% improvements in all body regions and components faster on ETN 50 mg BIW/QW than QW/QW (all P <0.05). Median time to 75% improvement was faster for the head and trunk followed by upper and lower extremities, and for induration and desquamation followed by erythema and total area. Weak to moderately positive correlations between improvements in DLQI and PASI total score (range, r=0.223–0.463), all PASI body-specific (r=0.114–0.432) and component-specific (r=0.178–0.478) subscales were observed over 24 weeks.

Conclusions:
Etanercept treatment-response appears to occur in a body- and component-specific manner. Changes in quality of life are not captured by either PASI or its subscales.

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