Bill's pure dimethylfumarate thread

[Caroline]

Hi Caroline

I dont think the question of Kyle Bass' character matters much. He is simply trying to exploit an opportunity. I am far more concerned by the vast number of specialists who do not challenge the status quo. Because of the unusual status of DMF as both a pharmaceutical and industrial chemical (bisphosphonates are another, but are a class of chemicals), it could enable health services around the world to treat patients more effectively and at lower cost. It is sad to see instead the public interest abandoned for the sake of sweet deals with pharmaceutical companies.

I will take my next dose of DMF between two flattened jelly beans!

Cheers,

Bill

I agree with you Bill, it is so sad that the greedy people over and over again are making money over the backs of the people who need medicine so much. This morning I read about a girl in Greece who is developing MS, costs € 700 a month. For now this is still delivered, but because of the Greece problems it is quite undefined if this will continue.
She would be helped with e.g. cheap DMF.
Within the TPP negotiations you can also easily see that the benefit is going to the big pharma companies. It is all going in the wrong direction, the greedy direction, under the steering of Barack Obama. And it is all secret and later on thus voted upon by idiots who do not know what they are voting about.

I can be so mad about this practices

Cheers,
Caroline

[jiml]

Hi Caroline

I dont think the question of Kyle Bass' character matters much. He is simply trying to exploit an opportunity. I am far more concerned by the vast number of specialists who do not challenge the status quo. Because of the unusual status of DMF as both a pharmaceutical and industrial chemical (bisphosphonates are another, but are a class of chemicals), it could enable health services around the world to treat patients more effectively and at lower cost. It is sad to see instead the public interest abandoned for the sake of sweet deals with pharmaceutical companies.

I will take my next dose of DMF between two flattened jelly beans!

Cheers,

Bill

I agree with you Bill, it is so sad that the greedy people over and over again are making money over the backs of the people who need medicine so much. This morning I read about a girl in Greece who is developing MS, costs  € 700 a month. For now this is still delivered, but because of the Greece problems it is quite undefined if this will continue.
She would be helped with e.g. cheap DMF.
Within the TPP negotiations you can also easily see that the benefit is going to the big pharma companies. It is all going in the wrong direction, the greedy direction, under the steering of Barack Obama. And it is all secret and later on thus voted upon by idiots who do not know what they are voting about.

 I can be so mad about this practices  

Cheers,
Caroline

Stay mad at them Caroline, and shout very loudly so the voice of the people will be heard, before its to late  

[Caroline]

It is a rotten disease and you have my sympathies. I was reading about hematopoietic stem cell transplantation (not with regard to psoriasis) and realised it was the possible permanent cure that Caroline was talking about, although I am a little skeptical about its efficacy. What did interest me was the idea that auto-immune disease can result from specific leukocyte clones which tend to displace other lineages. HSCT attempts to restore variation to the immune system, although it is a little less successful at this with one type of T cell. The disease model fits for psoriasis, where it is easy to imagine a plaque causing lineage of T lymphocytes becoming dominant and wreaking havoc. Maybe DMF works by creating a better balance of leukocytes?

Anyway, good luck with your treatment. I think I can definitely add curries to the list of no-go foods for DMF. No headache thankfully, but a kick in the guts I could have done without.

Cheers,

Bill

Hi Bill,

This is a split from the Stelara thread post RE: Stelara round two as we were stealing Fred's thread.

I think what you are suggesting is very interesting and maybe it is indeed the treatment I am pointing to, or better said referring to. I am not sure though. Stem cell transplantation is very complex. The treatment I am referring to is an already very old technique that slipped into oblivion because of the fact that much easier medication came available for several immune approaches like the histamines, antibiotics, etc, that work immediately while the old treatment will take you at least a year.

The technique is described by Barger J A, Horgan E en Horgan J  in 1929 in the ‘Journal of American Medical Association’ called auto vaccination.

The site where I got this from is the site of the same doctor that developed Psorinovo. Unfortunately for you the whole site is in Dutch. You can get the link from me, but translating this complete site is quite a bit too much. The descriptions are extensive.
I can deliver a reading list of articles that are in English if you can find them anyway on the Internet.

Another approach has a.o. to do with the diversity of the intestine bacteria. That is where FMT Faecestransplantation is pointing at, think of Crohn's disease.

Caroline

[Bill]

Yes, it is interesting. My only concern with things like HSCT is whether the disease can recur. I think it would be very annoying to undergo an expensive and dangerous procedure, only to see the disease come back. Even with my own disease reducing, I occasionally get the odd spot forming.

Despite the hassle of DMF, I do not think that there is a better drug for me. It is working better than ever after over 30 months, and I can still enjoy curries and bananas as long as I dont have them with my doses.

I will see if I can find any research on the specific effects of DMF on lymphocytes.

Cheers,

Bill

[jiml]

I'm glad you can still enjoy a good curry and bananas,...... It worried me that you said they were a Nono, but they only affect you if you eat them with your dose ... Phew neither affect me at any time

Regarding stem cell transplant I find the subject extremely interesting but share your concern regarding the disease reoccurring..

[Bill]

Thank you, Jim. The food reactions are undoubtedly from taking the drug raw, but as I believe I am getting a greater efficacy from the rapid absorption I will keep taking it this way. You and Caroline might be interested in this article on the current understanding of DMF.

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

It is very technical but indicates that DMF seems to target the inflammatory process in many ways. That might explain why it is effective for both my p and psa.

Cheers,

Bill.

[jiml]

Thank you, Jim. The food reactions are undoubtedly from taking the drug raw, but as I believe I am getting a greater efficacy from the rapid absorption I will keep taking it this way. You and Caroline might be interested in this article on the current understanding of DMF.

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

It is very technical but indicates that DMF seems to target the inflammatory process in many ways. That might explain why it is effective for both my p and psa.

Cheers,

Bill.

I will certainly look it up and have a read and see how much I can understand
Thanks for the information

[Bill]

I am sure you will have no problem, Jim. It is a very well written review.

Cheers,

Bill

[jiml]

I am sure you will have no problem, Jim. It is a very well written review.

Cheers,

Bill

I'll let you know what I think later

[Bill]

And for something more technical try this:

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

Cheers,

Bill