Bill's pure dimethylfumarate thread

[jiml]

Another test result.



Lymphocytes normal, but not increased as much as I would like. I had a four week break from dosing after the cold started. There is the possibility that NAC may be an antagonist to DMF (Dimethylfumarate Induces Immunosuppression via Glutathione Depletion and Subsequent Induction of Heme Oxygenase 1). I will continue with twice weekly dosing at 600mg without NAC and see if there is any difference. Another blood test in three months.

Cheers

Great results still Bill it's nice to see them staying steady and within the normal range

I agree three monthly is plenty unless there is a drop below 1 for a prolonged period. I know I have mine done monthly and there is no real need for it as my lymphocytes are  within normal parameters most of the time although monthly does show up that when there's an infection the lymphocytes do drop and can drop below 0.7 but spring back fairly quickly when the infection passes  
I must put some recent figures in my journal although they will be much the same as those already posted

[Grizzly Bear]

Interesting indeed Bill.

Lymphocytes normal you say but not increased as much as you want ?
How much would you like it mate ?
Fingers crossed that you get Lymphocytes where you need it buddy.


From memory Bill, how cold does it get down under in your winter mate ?

Ours is flipping freezing normally which doesn’t help us psoriasis sufferers.


Cheers Bill mate

[Bill]

Thanks, Jim. I agree that once you have a number of test results you can get an appreciation of how stable your result will be. For example, by continuing my current regime (twice weekly 830mg with NAC) I would expect my next test to give a lymphocyte count from 0.9-1.1, with 0.8 the lowest possibility.

More predictable by experience. Unpredictable from theorising.

Cheers

[Bill]

Thanks Andy.

A lymphocyte count in the normal range would be good, but it is okay where it is. Not much disease, so I guess that is the main thing.

A handful of days here have minimums under 5C. Nine months of the year are good, but mid-December to mid-March can be a bit muggy. I hope you get some more comfortable stuff soon.

Cheers

[Raxyl]

Congratulations Bill, I’m still in awe of your approach.

[Bill]

Thanks, Craig. It isn't fun, but it works very well.

Cheers

[Fred]

Thanks, Craig. It isn't fun, but it works very well.

Cheers

It's fun for us reading it Bill.

Keep it up.

[Bill]

Glad you enjoy it, Fred. The 600mg dose is so much easier. I hope it works.

Cheers

[Fred]

Glad you enjoy it, Fred. The 600mg dose is so much easier. I hope it works.

Cheers

Just been thinking Bill it's been what 6 years now and you're still playing with the dose. Do you know of anyone else following you that you could compare dosage with ?

[Bill]

Trying to reduce the dose as the disease reduces is what you do with dimethyl fumarate, and requiring less drug with time is not uncommon. It may be that the n-acetyl cysteine that I have been taking to ameliorate the tummy upset with dimethyl fumarate is acting as an antagonist. I don't know if this is so, but if it is I may get as much effect from the smaller dose. I will find out soon enough. It would be very nice to have a routine that I did not have to review, but I had a drop in lymphocytes that I don't know the cause of which necessitated a dose reduction and prompted a search for something to bump up the count. Eighteen months later and I thought maybe I could keep the lymphocytes at a good level with a little iron supplementation, but with that addressed I have not seen the increase in lymphocytes sustained. Meanwhile I have noted that my disease is less active anyway, so that is another reason to try a lower dose for a while.

I hope that makes things a little clearer, Fred. For me, treating p and psa is like walking through a forest blindfolded. It is an excellent drug, but it is not set and forget.

Cheers