Fri-03-06-2016, 10:21 AM
(Fri-03-06-2016, 04:03 AM)mataribot Wrote: The folic acid isn't necessary - it's to prevent side effects. Taking too much may mask deficiencies. If you can live the SEs, then forgetting the FA isn't the end of the world.
" Studies have examined the effectiveness of folate supplementation in decreasing adverse effects associated with low-dose MTX. A Cochrane Review evaluated 7 randomized, double-blind, placebo-controlled trials that assessed whether folinic acid or folic acid decreased side effects of MTX in patients with RA. Both folinic acid and folic acid were found to decrease gastrointestinal and mucosal side effects"
As mataribot said it's just to reduce side effects but the studies do show that it works though the other conclusion was that higher doses were no more effective. I use to find that for me when I was on MTX it did reduce the side effects for me.
Dave