Health Boards
Sun-01-05-2016, 19:59 PM
Hi William, (here is the DMF gang, not to be mixed up by the Stelara gang 
)
This information is already available for at least thirty years or more.
Therefore the build up of using the medication being it Fumaderm or Psorinovo has to be very slow. The protocol for e.g. Psorinovo is very strong in that, what also holds for Fumaderm.
Tecfidera's protocol for building up is very fast, in a few weeks you go from 240 a day to the full dose. To my idea that is very much too fast.
Still there are in thirty years only a few cases of PML. They are arguably the result of not following the protocol or not stopping the medication if the lymphocytes get too low. I personally have spoken on the phone with one of the victims where this was the case, she blamed the medication, but in fact did not follow the protocol.
It is very strange that because of a few isolated cases everyone seems to shout around that DMF would be dangerous. Well it is not more dangerous than any of the other medications that are available.
But..... it is relatively cheap... My guess is that pharma likes selling more expensive medications far better.
In the Netherlands a scientific reseach on DMF is now coming very much closer where the leading dermatologists of the Netherlands are in involved. One of them is already combining the use of biologicals and DMF in one treatment.
The possibilities of DMF seem unlimited. Psoriasis, MS, Crohns, Lupus, decubitus. Who knows what we are still going to find on this compound.
Your low dose should at least keep you far out of range of too low lympho's.
Cheers,
Caroline
)This information is already available for at least thirty years or more.
Therefore the build up of using the medication being it Fumaderm or Psorinovo has to be very slow. The protocol for e.g. Psorinovo is very strong in that, what also holds for Fumaderm.
Tecfidera's protocol for building up is very fast, in a few weeks you go from 240 a day to the full dose. To my idea that is very much too fast.
Still there are in thirty years only a few cases of PML. They are arguably the result of not following the protocol or not stopping the medication if the lymphocytes get too low. I personally have spoken on the phone with one of the victims where this was the case, she blamed the medication, but in fact did not follow the protocol.
It is very strange that because of a few isolated cases everyone seems to shout around that DMF would be dangerous. Well it is not more dangerous than any of the other medications that are available.
But..... it is relatively cheap... My guess is that pharma likes selling more expensive medications far better.
In the Netherlands a scientific reseach on DMF is now coming very much closer where the leading dermatologists of the Netherlands are in involved. One of them is already combining the use of biologicals and DMF in one treatment.
The possibilities of DMF seem unlimited. Psoriasis, MS, Crohns, Lupus, decubitus. Who knows what we are still going to find on this compound.
Your low dose should at least keep you far out of range of too low lympho's.
Cheers,
Caroline