[split] Methotrexate Booklet

[D Foster]

A study on ehealthme reports:

Quote:

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Review: could Methotrexate cause Pml (Progressive multifocal leukoencephalopathy)?
.Summary: Pml is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Prednisone, and have Rheumatoid arthritis. We study 130,064 people who have side effects while taking Methotrexate from FDA and social media. Among them, 246 have Pml.


Methotrexate
Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from 131,421 Methotrexate users)

Pml
Pml (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis. (latest reports from 5,174 Pml patients)

On Apr, 5, 2016: 130,055 people reported to have side effects when taking Methotrexate. Among them, 246 people (0.19%) have Pml.
Trend of Pml in Methotrexate reports
Time on Methotrexate when people have Pml * :
< 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Pml 3.03% 36.36% 21.21% 0.00% 6.06% 27.27% 6.06%
Gender of people who have Pml when taking Methotrexate * :
Female Male
Pml 64.86% 35.14%
Age of people who have Pml when taking Methotrexate * :
0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Pml 0.00% 0.41% 7.85% 4.13% 3.31% 16.94% 24.38% 42.98%

People who are taking MTX for rheumatoid arthritis are taking much higher doses than we do for P or even PsA so any conclusions would not apply to P sufferers .