Low energy levels on fumaderm

[Bill]

It was the case of the patient with a 0.8 count getting PML that caused the concern. There is also concern that the JC virus may also act more slowly and cause dementia over a longer period. I stress this is speculative, but now that DMF is being used on large numbers of patients the uncommon side effects can be a problem. Personally I find DMF to be neuroprotective, but I wouldn't go as far as saying that the caution is an over-reaction. It would be nice if MTX were treated with the same level of concern instead of presenting statistical marvels to show how great it is.