Canada gets topical patch for psoriasis

[Fred]

I read somewhere that a patch is being developed for the administration of bio's ,it has a new type of surface compromising of "nano needles" for want of a better description that will penetrate the skin without causing problems with nerve penetration/stimulation. I will try to remember where I saw it.

It was in Nano Letters March 2015

Quote:

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Transdermal delivery of therapeutics is restricted by narrow limitations on size and hydrophobicity. Nanotopography has been shown to significantly enhance high molecular weight paracellular transport in vitro. Herein, we demonstrate for the first time that nanotopography applied to microneedles significantly enhances transdermal delivery of etanercept, a 150 kD therapeutic, in both rats and rabbits. We further show that this effect is mediated by remodeling of the tight junction proteins initiated via integrin binding to the nanotopography, followed by phosphorylation of myosin light chain (MLC) and activation of the actomyosin complex, which in turn increase paracellular permeability.

Source: acs.org