Bill's pure dimethylfumarate thread

[Caroline]

Bill, I did some research.

(Don't ask me how, that is secret )

A real and well knowledged doctor is behind this information. Not a dermatologist, no a real doctor.

The fact that taking the DMF intermittent  has a better effect  is already known since 1985....  It is even described in the magazine  Integrale Geneeskunde  on p 23 about taking fumarates with the treatment of psoriasis, and it says:" The intermitted taking of this preparate normally gives the best results with the least side effects".

So  your experiences confirm that the treatment of psoriasis with fumarate  still  can be enhanced

lymphopenia  can be induced by excessive physical training and can be reduced by cysteine.
Cysteine is quite harmless. It is a sulphuric amino acid which is  found in meat eggs cheese milk etcetera.

Some questions  from my contact :
How many Cysteïne did you have to use to get a normal lymphocyte value again? And what was the beginning count?
How did you make the capsules with DMF that pass your stomach ?

Comments from my contact: Psorinovo has been made to support the patients that have trouble in their intestines when taking DMF  in order to reduce the side-effects.


And here an article on the effects of cysteine  with heavy physical exercise .

Quote:

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ABSTRACT: BACKGROUND: Intense exercise induces increased blood neutrophil counts and decreased lymphocyte counts, and leads to inflammation and immunosuppression. It was previously reported that cystine and theanine (CT) supplementation by long-distance runners before a training camp suppressed the changes of these blood parameters observed in un-supplemented control subjects after the camp. The purpose of the present study was to determine the effects of CT supplementation on the inflammatory response and immune state before and after intense endurance exercise in long-distance runners at a training camp. METHODS: Sixteen long-distance runners were allocated to one of two groups given CT supplements (700 mg cystine + 280 mg theanine daily) or placebo (8 in each group) for 7 days prior to and during a 9-day training camp. Daily run training averaged 19.9 km/day prior to the camp and 28.6 km/day during the camp. On the initial and final days of the camp, blood samples were collected before and after 15 km morning interval running workouts (1000 m x 15 times) and analyzed for neutrophil and lymphocyte counts and myoglobin. RESULTS: The relative change in exercise-induced blood neutrophil count (% of pre-exercise values) was significantly lower in the CT group than in the placebo group (163.3 +/- 43.2% vs. 200.4 +/- 19.6%, p = 0.044) on the initial day of camp, but not on the last day. The decline in lymphocyte count (% of pre-exercise values) was significantly less in the CT group than in the placebo group (60.2 +/- 19.2% vs. 36.2 +/- 12.0%, p = 0.010) on the initial day of camp, but not on the last day. In blood myoglobin, there was a trend toward lower % of pre-exercise values in the CT group (p<0.09) on both measurement days. CONCLUSION: CT supplementation significantly attenuated the increase in neutrophil count and the reduction in lymphocyte count induced by intense endurance exercise. These results suggest that CT supplementation may suppress the exercise-induced fluctuation of the blood immunocompetent cells and may help to reduce the alteration of the immune state.

Cheers,
Caroline