Starting MTX

[Fred]

one question is how soon should I start to notice any effect, besides throwing up the morning after I take them?

Sorry I forgot to give my answer to this bit.

You probably won't throw up, it's just the feeling it can give you but not many people are actually sick with it.

I would say Nauseas and feeling like a Zombie are the first things you will notice.

For some of the most common side effects see this thread: Methotrexate But remember we are all different.

As for effect on psoriasis it never done anything for me.