Health Boards
Fri-03-04-2015, 09:18 AM
Hi all 
I would like to share another clinical study.
It's about palm Psoraisis and Dupuytrens contractore. I have it very bad palmoplantar P. and have managed to contol it thru a constant regime. If anyone is interested I will be happy to share. It's on the bottoms of my feet too! 
What the clinical study I read about actually found a connection between Dupuytrens Contracture & a high % of the patients had DC also had palm Psoriasis. Much is not understood by many doctors about treatment of DC.
Dupuytrens is the thickening of palm tendons & nodules pulling the tendons in while also pulling the fingers into a curl. There is no cure. It's the collagen constantly attacking the tendons as the antibodies send out signals to the tendons the same way that plaque psoriasis is in overdrive building up skin before shedding can occur. Thru the interluken pathway found in psoriasis, a lot of new drugs block that pathway the IL-17 or the
IL-23 both for Psoriasis and psoriatic psoriasis. Both which are the same pathways extra collagen is building up on tendons causing Dupuytrens Contracture. That was the connection in the clinical study.
I have had surgery, needle apenuroctomy and biologic drug injections in the fingers called XIAFLEX. The bio drug opened the 4th & fifth fingers from a closed position that surgery caused. At the time of surgery palmoplanter psoriasis flared and also the Dupuytrens flared in all four fingers.
Long story short
the XIAFLEX also removed all the scar tissue from the surgery to open my frozen shut fingers. Now the bio drug is in another study to help burn victums and removing scar tissue from burn victims, surgeries etc. This is not a bio drug for the faint of 
This bio drug has many painful side effects. My fingers are still painful after 2 months and swollen. A splint is worn nightly for a year. Hand therapy for use to strengthen fingers is important for continued use, hopefully. 
my hand is still in a claw position and does not lay flat on a table with limited movement. 
The bad news my fingers are curling again.
I am suspicious that there could be another issue in my case at work here.
The Keobner Phenomenon.
This is when anything can set off a reaction such as surgery, insect bite with DC & Psoriasis in my case then causes a flare . In my experience every time I try something to help my claw hand, it just makes it flare and far worse. However, at least the XIAFLEX a enzyme totally eliminated the thicken scar tissue and now my two fingers are not curled in a fist like position. I can put on my garden gloves. 
and shake hands.
If you have hand P. & you have nodules on the tendons & thickened tendons that predominantly show up in your palm or both it could be DC.
I hope this makes sense. Please google the psoriasis & Dupuytrens contracture clinical study for more info.
Have a good day !
I would like to share another clinical study.
It's about palm Psoraisis and Dupuytrens contractore. I have it very bad palmoplantar P. and have managed to contol it thru a constant regime. If anyone is interested I will be happy to share. It's on the bottoms of my feet too! What the clinical study I read about actually found a connection between Dupuytrens Contracture & a high % of the patients had DC also had palm Psoriasis. Much is not understood by many doctors about treatment of DC.
Dupuytrens is the thickening of palm tendons & nodules pulling the tendons in while also pulling the fingers into a curl. There is no cure. It's the collagen constantly attacking the tendons as the antibodies send out signals to the tendons the same way that plaque psoriasis is in overdrive building up skin before shedding can occur. Thru the interluken pathway found in psoriasis, a lot of new drugs block that pathway the IL-17 or the
IL-23 both for Psoriasis and psoriatic psoriasis. Both which are the same pathways extra collagen is building up on tendons causing Dupuytrens Contracture. That was the connection in the clinical study.
I have had surgery, needle apenuroctomy and biologic drug injections in the fingers called XIAFLEX. The bio drug opened the 4th & fifth fingers from a closed position that surgery caused. At the time of surgery palmoplanter psoriasis flared and also the Dupuytrens flared in all four fingers.
Long story short
the XIAFLEX also removed all the scar tissue from the surgery to open my frozen shut fingers. Now the bio drug is in another study to help burn victums and removing scar tissue from burn victims, surgeries etc. This is not a bio drug for the faint of This bio drug has many painful side effects. My fingers are still painful after 2 months and swollen. A splint is worn nightly for a year. Hand therapy for use to strengthen fingers is important for continued use, hopefully. my hand is still in a claw position and does not lay flat on a table with limited movement. The bad news my fingers are curling again.
I am suspicious that there could be another issue in my case at work here.The Keobner Phenomenon.
This is when anything can set off a reaction such as surgery, insect bite with DC & Psoriasis in my case then causes a flare . In my experience every time I try something to help my claw hand, it just makes it flare and far worse. However, at least the XIAFLEX a enzyme totally eliminated the thicken scar tissue and now my two fingers are not curled in a fist like position. I can put on my garden gloves. and shake hands. If you have hand P. & you have nodules on the tendons & thickened tendons that predominantly show up in your palm or both it could be DC.
I hope this makes sense. Please google the psoriasis & Dupuytrens contracture clinical study for more info.
Have a good day !