Fumaderm advice wanted

[jiml]

Hi again Cathy I've just returned home, and have a bit more time to write .. Welcome to the forum I'm glad you have found us and chosen to post here, you have no doubt had a look through the site and seen that it is a happy site to belong to, we are all always happy to offer and receive support for the various treatments we are on, and the site is lively and current, I see that Caroline and Kath have both posted and both have also had experience of DMF as Fumaderm or Psorinovo and can give you some valuable advice...

Regarding your side effects on Fumaderm they are not unusual but there are things you may be able to do to reduce the severity of the cramps and nausea.
Are you taking your tablets with meals?
Are you taking plenty of fluid to flush them down
I have to admit the side effects for me were not horrendous the cramps were bad but short lived. I never felt nauseous ...... It may be to do with the way you are taking them.
Do let us know some more detail as Kath and Caroline have asked about

This may be of interest it is part of an article from medscape and the full document is available

Quote:

---

Common adverse events associated with FAE therapy for psoriasis are gastrointestinal complaints and flushing.[74] Gastrointestinal adverse events, such as diarrhoea, mild stomach upsets, stomach cramps, fullness and flatulence, occur in more than two-thirds of patients and are most frequently reported between 4 and 12 weeks of treatment.[74,75] Approximately one-third of patients experience flushing, characterized by reddening of the face and a sensation of heat, sometimes associated with headache, lasting minutes to hours. Flushing occurs most often at the onset of treatment and becomes less frequent with further exposure.[74]

Clinical experience has shown that the gastrointestinal adverse effects of FAE therapy may be controlled with aluminium hydroxide, metoclopramide or ranitidine.[82] There is also some evidence that concomitant pentoxifylline therapy may reduce the incidence and severity of gastrointestinal complaints and flushing in patients receiving FAE therapy.[83] FAE dose reduction may also be used to manage symptoms; however, discontinuation should be considered in persistent cases.[75] Gastrointestinal adverse events and flushing together lead to discontinuation of FAE therapy in approximately 7% of patients.[74] Overall, the rate of discontinuation due to adverse events and/or noncompliance with treatment is 30-40%.[34]

Source medscape