Fumaderm advice wanted

[jiml]

Thanks for the responses :-) Sorry its taken me a while to reply...busy weekend!

Feeling pretty ill on the 8 a day regime, but I got used to that from when I went up to 6!

I have a blood test booked in a couple of weeks so at least I'll get an idea of whether the high dose is having any negative effects. I had a chat with my Dermatologist about it becasue the BAD advice was 6 tablets max per day, but in Germany the max is 12!

My Derm also told me that its not licensed here because they have not done the research to determine which of the 4 esters are 'active ingredients' (i.e. provide the clinical benefits). I'm not sure how accurate this is but I do find it interesting, and the fact that it can be prescribed here on the NHS without being licensed!

Caroline - I'll definitely have a look at your post when I get the chance...interesting stuff!

Kath  

Thanks for that information it is interesting I shall have to do some more research regarding the maximum dose in Germany. i hope your blood test comes back with good results and the side effects subside. Thanks again, and good luck

Hi Just had a look and found this

Quote:

---

Current German guidelines recommend a gradual increase in FAE dosage to determine optimal efficacy and tolerability for each patient. During the first week of treatment, patients typically receive one tablet daily of a low-strength 'Fumaderm® initial' formulation (30 mg dimethylfumarate; 75 mg monoethylfumarate as Ca, Mg and Zn salts), increasing over the next 8 weeks to a maximum of six tablets daily of full-strength Fumaderm® (120 mg dimethylfumarate; 95 mg monoethylfumarate as Ca, Mg and Zn salts) taken as a divided dose of two tablets three times daily.[74,75] Clinical benefit is typically observed after 4-6 weeks of treatment.[75] Following psoriasis remission, use of a reduced dose for maintenance should be attempted.[75]

This was an extract from this document
[link hidden]