Health Boards
Sat-07-02-2015, 03:59 AM
The different bios target different pathways and proteins.
For psoriatic P. Interleukin 12/23
Stelara (ustekinumab) works by selectively targeting the proteins, or cytokines, interleukin-12 (IL-12) and interleukin 23 (IL-23). Interleukins-12/23 are associated with psoriatic inflammation.
How are they used?
The biologics are taken by injection or by IV infusion. Cimzia, Cosentyx, Enbrel, Humira and Simponi are injected in the legs, abdomen or arms, typically by the individual with psoriatic disease or a family member. Stelara is administered as a subcutaneous injection by a health care provider. Remicade is given through IV infusion in a doctor’s office or infusion center. Biologics are prescribed for individuals with moderate to severe cases of plaque psoriasis and psoriatic arthritis. They are a viable option for those who have not responded to or have experienced harmful side effects from other treatments. Studies show that TNF-alpha blockers help reduce the progression of joint damage in psoriatic arthritis.
Also newly approved Apremilast works by regulating the inflammatory network within the body's cells. It targets an enzyme known as phosphodiesterase 4, or PDE4, which promotes the production of pro-inflammatory messengers and decreases the production of anti-inflammatory messengers within cells. Better regulating PDE4 can help reduce inflammation in skin and joints.
The more we learn the more we understand this disease. Many are used off label for other autoimmune diseases.
For psoriatic P. Interleukin 12/23
Stelara (ustekinumab) works by selectively targeting the proteins, or cytokines, interleukin-12 (IL-12) and interleukin 23 (IL-23). Interleukins-12/23 are associated with psoriatic inflammation.
How are they used?
The biologics are taken by injection or by IV infusion. Cimzia, Cosentyx, Enbrel, Humira and Simponi are injected in the legs, abdomen or arms, typically by the individual with psoriatic disease or a family member. Stelara is administered as a subcutaneous injection by a health care provider. Remicade is given through IV infusion in a doctor’s office or infusion center. Biologics are prescribed for individuals with moderate to severe cases of plaque psoriasis and psoriatic arthritis. They are a viable option for those who have not responded to or have experienced harmful side effects from other treatments. Studies show that TNF-alpha blockers help reduce the progression of joint damage in psoriatic arthritis.
Also newly approved Apremilast works by regulating the inflammatory network within the body's cells. It targets an enzyme known as phosphodiesterase 4, or PDE4, which promotes the production of pro-inflammatory messengers and decreases the production of anti-inflammatory messengers within cells. Better regulating PDE4 can help reduce inflammation in skin and joints.
The more we learn the more we understand this disease. Many are used off label for other autoimmune diseases.