Delphinidin could be worth looking into for treatment of psoriasis.

[Fred]

This study on Mice looked at the possibilities of a topical application of delphinidin modulating the pathological markers of psoriasiform lesions in flaky skin, delphinidin is a plant pigment, and also an antioxidant. It gives Blue Hues to to plants and fruits such as Delphinium, Cranberries, Pomegranates, the Cabernet Sauvignon grape. (Could be time to switch from the Merlot Fred)

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Background:
Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and aberrant keratinocyte differentiation. We have shown that treatment of reconstituted human skin with delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, increased the expression and processing of caspase-14, which is involved in cornification. Delphinidin also increases the expression of epidermal differentiation marker proteins.

Objectives:
To determine whether topical application of delphinidin can modulate pathological markers of psoriasiform lesions in flaky skin mice and if this is associated with increased epidermal differentiation and a reduction in proliferation and inflammation.

Methods:
Five-week-old female homozygous flaky skin mice (fsn/fsn) were treated topically with delphinidin (0·5 mg cm−2 and 1 mg cm−2 skin areas, respectively), five times a week, up to 14 weeks of age.

Results:
Treatment of flaky skin mice with delphinidin resulted in a reduction in (i) pathological markers of psoriasiform lesions; (ii) infiltration of inflammatory cells; and (iii) mRNA and protein expression of inflammatory cytokines. Delphinidin treatment also increased the expression and processing of caspase-14, and expression of filaggrin, loricrin, keratin-1 and keratin-10. Furthermore, there was a decrease in the expression of markers for cell proliferation (proliferating cell nuclear antigen and keratin-14) and modulation of tight junction proteins (occludin and claudin-1). In addition, delphinidin treatment increased the expression of activator protein-1 transcription factor proteins (JunB, JunD, Fra1 and Fra2).

Conclusions:
Delphinidin could be a promising agent for treatment of psoriasis and other hyperproliferative skin disorders.

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Funded by:
National Institutes of Health. Grant Numbers: R21 AT004966, RO1 AR059742
University of Alabama Skin Disease Research Center Pilot and Feasibility. Grant Number: P30AR50948