Psoriasis patients have higher risk of kidney disease

[Fred]

This study looked at the risk of kidney disease in people with psoriasis and psoriatic arthritis, it suggests they are at higher risk and that the use of Nonsteroidal anti-inflammatory drugs (NSAIDs) increases that risk.

Quote:

---

Background:
Few studies have examined the association between psoriasis and glomerulonephritis (GN) as well as chronic kidney disease (CKD).

Objectives:
To determine the risk of CKD in patients with psoriasis and evaluate the impact of the severity of psoriasis, comorbidities, and concomitant medications on the risk of GN and CKD in patients with psoriasis.

Methods:
We identified 4344 patients with psoriasis for the study cohort and randomly selected 13032 subjects as a control cohort. Each subject was individually followed up for a 5-year period to identify those who subsequently developed GN and CKD.

Results:
After adjustment with traditional CKD risk factors, psoriasis was found to be independently associated with an increased risk of CKD during the 5-year follow-up period (hazard ratio (HR), 1.28; 95% confidence interval (CI), 1.14-1.44). The increased incidence GN in psoriasis patients (HR, 1.50; 95% CI, 1.24-1.81) may partly contributed to the positive association between psoriasis and CKD. Both patients with mild and severe psoriasis had an increased risk of CKD and GN compared with control cohort and the risk increased with severity. Psoriasis patients with arthritis exhibited a higher risk of CKD than patients without arthritis (HR, 1.62 vs. 1.26). Among medication, nonsteroidal anti-inflammatory drugs (NSAIDs) have the strongest association with CKD in patients with psoriasis (Adjusted Odds Ratio, 1.69; 95% CI, 1.14-2.49).

Conclusions:
Psoriasis was associated with a higher risk of developing CKD and GN. High severity, psoriatic arthritis involvement and concomitant NSAIDs use further increased the risk of CKD in patients with psoriasis.

Source: [link hidden]

*Early publication, no funding shown.