Association between psoriasis and depression

[Fred]

Quote:

---

The inflammatory hypothesis has been proposed to explain the potential association between psoriasis and depression. Several retrospective studies suggested that the standard of assorted inflammatory cytokines and cells is significantly elevated in psoriasis patients compared to the normal population. Meanwhile, a prospective longitudinal observational research indicated that psoriasis patients with systemic treatment had a prominent reduction in the blood inflammatory parameters. In addition, previous researches find inflammation is essential for the pathogenesis of depression. The exacerbation of inflammation contributes to its development and worsening. A clinical study found that nearly half of all cancer patients suffer from mood disturbances after taking interferon-alpha, especially depression. Antidepressant treatment also significantly reduces the level of inflammation in patients with depression. Meanwhile, anti-inflammatory therapy can improve antidepressant effectiveness and alleviate depressive symptoms, but the potential relationship between inflammation and depression remains unclear.

Nevertheless, the role of inflammation remains poorly understood in the relationship between psoriasis and depression. The study analyzed the humongous multiracial adult cohort to investigate whether inflammation is involved in the relevance between psoriasis and depression. Inflammatory reactions contribute to changes in the quantity and category of circulating immunocytes. Neutrophils, lymphocytes, and monocytes are essential in regulating the inflammatory response. Neutrophils serve a vital function in innate immunity and are involved in releasing cytokine, phagocytosis, and apoptosis in acute inflammation. Lymphocytes are key cells that connect innate and adaptive responses. Monocytes have a significant role in the innate immune system and coordinating inflammation. The neutrophil-to-lymphocyte ratio (NLR) is an easily measurable clinical biomarker that can reflect inflammation levels from a complete blood count (CBC). Moreover, the systemic inflammation response index (SIRI) is an innovative inflammatory biomarker. This biomarker is derived from the analysis of various immune cell subsets, along with the quantification of monocyte counts. Thus, the study chose NLR and SIRI as the systemic inflammatory biomarkers.

We aimed to explore the mediating role of SIRI and NLR in the association between psoriasis and depression. Therefore, this study was mainly validated around two key hypotheses: (1) There was a significant correlation between psoriasis, systemic inflammatory markers, and depression; (2) systemic inflammatory markers may serve as a partial mediator in the relationship between psoriasis and depression.