Efficacy & safety of IL-17 & IL-23 inhibitors in elderly psoriasis patients

[Caroline]

Great results for the elderly   

What I see is the following.
At 12/16 weeks, the < 65 group achieved significantly higher
PASI75 (90.5% vs. 65.1%, p = 0.010),
PASI90 (75.7% vs. 32.6%, p = 0.030) and
PASI < 2 (55.8% vs. 79.7%, p = 0.006)

At PASi75 the younger are doing significantly better than the elderly.
Identical for PASI90
But… for PASI < 2, which means almost complete or complete remission, the elderly suddenly do better.



That is quite not logical..

Maybe as we get older it helps, mine has got better the older I get but that could be down to Bimzelx. 

I would suspect that with age the body changes , hormone levels and things like that and the way the older person's body tolerance will make the difference but the younger body , taking in to consideration hormones etc , may not be as stable and takes time to adjust.

I think it is just a mistake, as it is totally not logical, and it should be the other way around.

I also think the younger body is way more flexible as the older body. I admit that there may be a stable period, but on the whole the older body gets worn out and inherently less stable.